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https://hdl.handle.net/1822/74139
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Campo DC | Valor | Idioma |
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dc.contributor.author | Llenas, Marina | por |
dc.contributor.author | Paoli, Roberto | por |
dc.contributor.author | Feiner-Gracia, Natalia | por |
dc.contributor.author | Albertazzi, Lorenzo | por |
dc.contributor.author | Samitier, Josep | por |
dc.contributor.author | Caballero, David | por |
dc.date.accessioned | 2021-09-24T09:56:32Z | - |
dc.date.available | 2021-09-24T09:56:32Z | - |
dc.date.issued | 2021-06-09 | - |
dc.identifier.citation | Llenas, M.; Paoli, R.; Feiner-Gracia, N.; Albertazzi, L.; Samitier, J.; Caballero, D. Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors. Bioengineering 2021, 8, 81. https://doi.org/10.3390/bioengineering8060081 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74139 | - |
dc.description.abstract | Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less utilized for investigating the distinctive features and functional heterogeneities of tumor-derived vascular networks. In particular, vascular tumors are characterized by the massive formation of thrombi and severe bleeding, a rare and life-threatening situation for which there are yet no clear therapeutic guidelines. This is mainly due to the lack of technological platforms capable of reproducing these characteristic traits of the pathology in a simple and well-controlled manner. Herein, we report the fabrication of a versatile tumor vessel-on-a-chip platform to reproduce, investigate, and characterize the massive formation of thrombi and hemorrhage on-chip in a fast and easy manner. Despite its simplicity, this method offers multiple advantages to recapitulate the pathophysiological events of vascular tumors, and therefore, may find useful applications in the field of vascular-related diseases, while at the same time being an alternative to more complex approaches. | por |
dc.description.sponsorship | D.C. received funding from the Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia and the COFUND program of the Marie Curie Actions of the 7th R&D Framework Program of the European Union (BP-DGR 2013). This work was partially funded by Spanish Science Ministry PCIN-2016-025 “Nanovacunas diseñadas para inmunoterapia antitumoral” (NANOVAX) EuroNanomed II platform, and PI20/0056 “Precision medicine in portal vein thrombosis: identification of new therapeutic targets and development of a unique theranostic approach”. Additionally, from the European Commission H2020-MSCA-ITN-2019, Grant Agreement N860436, “EVIDENCE”. The authors also thank the Spanish Ministry of Economy, Industry and Competitiveness through the project SAF2016-75241-R, the Obra Social La Caixa Foundation, and the European Research Council (ERC- StG-757397). The Nanobioengineering Group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2017 SGR 1079). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | SAF2016-75241-R | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | In vitro model | por |
dc.subject | Microfluidics | por |
dc.subject | Organ-on-chip | por |
dc.subject | Vascular tumor | por |
dc.subject | Vessel | por |
dc.title | Versatile vessel-on-a-chip platform for studying key features of blood vascular tumors | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2306-5354/8/6/81 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 13 | por |
oaire.citationIssue | 6 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2021-06-24T14:11:32Z | - |
dc.identifier.eissn | 2306-5354 | - |
dc.identifier.doi | 10.3390/bioengineering8060081 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Bioengineering | por |
oaire.version | VoR | por |
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bioengineering-08-00081-v2.pdf | 19,41 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons