Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74070
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Santana, Wanessa | por |
dc.contributor.author | de Oliveira, Simone S. C. | por |
dc.contributor.author | Ramos, Mariana H. | por |
dc.contributor.author | Santos, André L. S. | por |
dc.contributor.author | Dolabella, Silvio S. | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Severino, Patrícia | por |
dc.contributor.author | Jain, Sona | por |
dc.date.accessioned | 2021-09-20T08:51:15Z | - |
dc.date.available | 2021-09-20T08:51:15Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | Santana, Wanessa; de Oliveira, Simone S. C.; Ramos, Mariana H.; Santos, André L. S.; Dolabella, Silvio S.; Souto, Eliana; Severino, Patrícia; Jain, Sona, Exploring innovative Leishmaniasis treatment: drug targets from pre-clinical to clinical findings. Chemistry & Biodiversity, 18(9), e2100336, 2021 | por |
dc.identifier.issn | 1612-1872 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74070 | - |
dc.description.abstract | Leishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The conventional treatment is complex and can present high toxicity and therapeutic failures. Thus, there is a continuing need to develop new treatments. In this review, we focus on the novel molecules described in the literature with potential leishmanicidal activity, categorizing them in pre-clinical (invitro, invivo), drug repurposing and clinical research. | eng |
dc.description.sponsorship | This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico for the Scientific grants (CNPq 301964/2019-0 Chamada No. 06/2019, Chamada CNPq No. 01/2019) and Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through the sponsorship of the project M-ERA-NET-0004/2015-PAIRED (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020. We would like to thank Tiago Branquinho Oliveira for the help provided in drawing Figure 3. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-Blackwell | por |
dc.rights | openAccess | por |
dc.subject | Leishmaniasis | por |
dc.subject | New targets | por |
dc.subject | Pre-clinical | por |
dc.subject | Clinical | por |
dc.subject | Drug repurposing | por |
dc.title | Exploring innovative Leishmaniasis treatment: drug targets from pre-clinical to clinical findings | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100336 | por |
dc.comments | CEB54590 | por |
oaire.citationStartPage | e2100336 | por |
oaire.citationIssue | 9 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 18 | por |
dc.date.updated | 2021-09-18T19:52:20Z | - |
dc.identifier.doi | 10.1002/cbdv.202100336 | por |
dc.identifier.pmid | 34369662 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Chemistry & Biodiversity | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54590_1.pdf | 3,56 MB | Adobe PDF | Ver/Abrir |