Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74028
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mendanha, Daniel | por |
dc.contributor.author | Castro, Joana Isabel Martins Cosme Vieira | por |
dc.contributor.author | Moreira, Joana | por |
dc.contributor.author | Costa, Bruno Marques | por |
dc.contributor.author | Cidade, Honorina | por |
dc.contributor.author | Pinto, Madalena | por |
dc.contributor.author | Ferreira, Helena Susana Costa Machado | por |
dc.contributor.author | Neves, N. M. | por |
dc.date.accessioned | 2021-09-15T09:12:34Z | - |
dc.date.available | 2021-09-15T09:12:34Z | - |
dc.date.issued | 2021-06-03 | - |
dc.identifier.citation | Mendanha, D.; Vieira de Castro, J.; Moreira, J.; Costa, B.M.; Cidade, H.; Pinto, M.; Ferreira, H.; Neves, N.M. A New Chalcone Derivative with Promising Antiproliferative and Anti-Invasion Activities in Glioblastoma Cells. Molecules 2021, 26, 3383. https://doi.org/10.3390/molecules26113383 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74028 | - |
dc.description.abstract | Glioblastoma (GBM) is the most common and most deadly primary malignant brain tumor. Current therapies are not effective, the average survival of GBM patients after diagnosis being limited to few months. Therefore, the discovery of new treatments for this highly aggressive brain cancer is urgently needed. Chalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer agents. In this work, three chalcone derivatives were tested regarding their inhibitory activity and selectivity towards GBM cell lines (human and mouse) and a non-cancerous mouse brain cell line. The chalcone 1 showed the most potent and selective cytotoxic effects in the GBM cell lines, being further investigated regarding its ability to reduce critical hallmark features of GBM and to induce apoptosis and cell cycle arrest. This derivative showed to successfully reduce the invasion and proliferation capacity of tumor cells, both key targets for cancer treatment. Moreover, to overcome potential systemic side effects and its poor water solubility, this compound was encapsulated into liposomes. Therapeutic concentrations were incorporated retaining the potent in vitro growth inhibitory effect of the selected compound. In conclusion, our results demonstrated that this new formulation can be a promising starting point for the discovery of new and more effective drug treatments for GBM. | por |
dc.description.sponsorship | This research was funded by FCT to the PhD grant of DM fellowship (PD/BD/143038/2018) and the projects PATH (PD/00169/2013), FROnTHERA (NORTE-01-0145-FEDER-000023), Cells4_IDs (PTDC/BTM-SAL/28882/2017) and the NORTE 2020 Structured Project, co-funded by Norte2020 (NORTE-01-0145-FEDER-000021). This research was also supported by the Strategic Funding UIDB/04423/2020 and UIDP/04423/2020 (Group of Natural Products and Medicinal ChemistryCIIMAR) through national funds provided by the FCT and ERDF, within the framework of the program PT2020. Joana Moreira acknowledges her grant (SFRH/BD/135852/2018). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | PD/BD/143038/2018 | por |
dc.relation | PD/00169/2013 | por |
dc.relation | NORTE-01-0145-FEDER-000023 | por |
dc.relation | PTDC/BTM-SAL/28882/2017 | por |
dc.relation | NORTE-01-0145-FEDER-000021 | por |
dc.relation | UIDB/04423/2020 | por |
dc.relation | UIDP/04423/2020 | por |
dc.relation | SFRH/BD/135852/2018 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Glioblastoma | por |
dc.subject | Chalcone | por |
dc.subject | Cell death | por |
dc.subject | Drug delivery | por |
dc.subject | Liposomes | por |
dc.title | A new chalcone derivative with promising antiproliferative and anti-invasion activities in glioblastoma cells | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/26/11/3383 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 17 | por |
oaire.citationIssue | 11 | por |
oaire.citationVolume | 26 | por |
dc.date.updated | 2021-06-10T13:47:43Z | - |
dc.identifier.eissn | 1420-3049 | - |
dc.identifier.doi | 10.3390/molecules26113383 | por |
dc.identifier.pmid | 34205043 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecules | por |
oaire.version | VoR | por |
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Ficheiro | Descrição | Tamanho | Formato | |
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molecules-26-03383.pdf | 2,98 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons