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https://hdl.handle.net/1822/73809
Título: | The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
Autor(es): | Santos, Pedro Miguel Ferreira Carrón, Rosalía Montero, M. José Sevilla, M. Ángeles |
Palavras-chave: | Lycopene Aging SHR Cardiovascular Oxidative stress |
Data: | Ago-2021 |
Editora: | Elsevier 1 |
Revista: | Journal of Functional Foods |
Citação: | Ferreira-Santos, P.; Carrón, Rosalía; Montero, M. José; Sevilla, M. Ángeles, The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. Journal of Functional Foods, 85(104656), 2021 |
Resumo(s): | Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/73809 |
DOI: | 10.1016/j.jff.2021.104656 |
ISSN: | 1756-4646 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1756464621003054 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54569_1.pdf | 4,35 MB | Adobe PDF | Ver/Abrir |