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https://hdl.handle.net/1822/73530
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Campo DC | Valor | Idioma |
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dc.contributor.author | Rodrigues, Luísa Cidália Guimarães | por |
dc.contributor.author | Fernandes, Emanuel Mouta | por |
dc.contributor.author | Ribeiro, Ana R. | por |
dc.contributor.author | Ribeiro, Adriana P. | por |
dc.contributor.author | Silva, Simone S. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2021-07-05T15:02:07Z | - |
dc.date.issued | 2021-04 | - |
dc.date.submitted | 2021-03 | - |
dc.identifier.citation | Rodrigues L.C., Fernandes E. M., Ribeiro A. R., Ribeiro A. P., Silva S. S., Reis R. L. Physicochemical features assessment of acemannan-based ternary blended films for biomedical purposes, Carbohydrate Polymers, Vol. 257, pp. 117601, doi:10.1016/j.carbpol.2020.117601, 2021 | por |
dc.identifier.issn | 0144-8617 | por |
dc.identifier.uri | https://hdl.handle.net/1822/73530 | - |
dc.description.abstract | The exploitation of natural origin macromolecules, as complex physical mixtures or drugs, increases in biomedical or tissue engineering (TE) solutions. Aloe Vera is a highly explored medicinal plant, from which the main polysaccharide is acemannan (ACE). The ACE combination with chitosan and alginate results in interactions that lead to mixed junction zones formation, predicting membrane functionality improvement. This work proposes the development and characterization of ACE-based blended films as a promising strategy to design a nature-derived bioactive platform. The results confirmed that stable complex polyelectrolyte structures were formed through different intermolecular interactions. The films present good dimensional stability, flexibility, an adequate swelling ability with mostly radial water uptake, and a sustainable ACE release to the medium. Positive biological performance of the ACE-based blended films with L929 cells also suggested that they can be applied in TE solutions, with the potential to act as bioactive topical platforms. | por |
dc.description.sponsorship | L.C. Rodrigues especially acknowledges financial support from Portuguese FCT (SFRH/BPD/93697/2013). This work is also financially supported by the FCT R&D&I projects with references PTDC/CTM-BIO/ 4706/2014-(POCI-01-0145-FEDER-016716), PTDC/CTM-CTM/29813/ 2017-(POCI-01-0145-FEDER-029813), PTDC/BII-BIO/31570/2017, and R&D&I Structured Projects with reference NORTE-01-0145- FEDER-000021. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F93697%2F2013/PT | por |
dc.relation | PTDC/CTM-BIO/4706/2014 | por |
dc.relation | PTDC/CTM-CTM/29813/2017 | por |
dc.relation | PTDC/BII-BIO/31570/2017 | por |
dc.relation | NORTE-01-0145-FEDER-000021 | por |
dc.rights | restrictedAccess | por |
dc.subject | Acemannan | por |
dc.subject | ALGINATE | por |
dc.subject | Aloe vera | por |
dc.subject | bioactive agents | por |
dc.subject | BIOMEDICAL APPLICATIONS | por |
dc.subject | Blend Films | por |
dc.subject | Chitosan | por |
dc.subject | Blend | por |
dc.subject | Films | por |
dc.title | Physicochemical features assessment of acemannan-based ternary blended films for biomedical purposes | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S0144861720317744 | por |
dc.comments | http://3bs.uminho.pt/node/20497 | por |
oaire.citationVolume | 257 | por |
dc.date.updated | 2021-07-05T08:34:29Z | - |
dc.identifier.doi | 10.1016/j.carbpol.2020.117601 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 33541636 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Carbohydrate Polymers | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20497-Physicochemical features assessment of acemannan.pdf Acesso restrito! | 6,93 MB | Adobe PDF | Ver/Abrir |