Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72994
Título: | Functional characterization of putative acetate transporters and channels in the human fungal pathogen Candida glabrata |
Autor(es): | Alves, Rosana Maria Abreu Timmermans, Bea Van Ende, Mieke Casal, Margarida Van Dijck, Patrick Paiva, Sandra |
Data: | Ago-2019 |
Resumo(s): | Successful human colonizers such as Candida species have evolved distinct strategies to survive and proliferate within the human host. These strategies include sophisticated mechanisms to rapidly adapt to a diverse range of environmental stresses and assimilate the available nutrients. For instance, during gastrointestinal and vaginal colonization, where glucose is scarce, alternative carbon sources such as acetate or lactate are particularly abundant and may support the growth and the proliferation of C. glabrata cells. Our studies have demonstrated that the presence of these alternative non‐fermentable carbon sources influence biofilm formation, antifungal drug resistance and immune recognition. Additionally, there is evidence that putative acetate transporters and channels have an important impact on these processes. Here, we provide a detailed view on the role of putative C. glabrata acetate transporters during carbon adaptation. Our data support the view that adaptive responses of Candida cells to alternative carbon sources affect their virulence, through multifarious mechanisms. |
Tipo: | Comunicação oral |
URI: | https://hdl.handle.net/1822/72994 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CBMA - Comunicações/Communications in Congresses |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2019-Abstracts.pdf | 2,84 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons