Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70432
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Pinho, Diana | por |
dc.contributor.author | Carvalho, Violeta Meneses | por |
dc.contributor.author | Gonçalves, Inês M. | por |
dc.contributor.author | Teixeira, S. F. C. F. | por |
dc.contributor.author | Lima, Rui Alberto Madeira Macedo | por |
dc.date.accessioned | 2021-02-25T12:05:31Z | - |
dc.date.available | 2021-02-25T12:05:31Z | - |
dc.date.issued | 2020-12-01 | - |
dc.identifier.issn | 2075-4426 | - |
dc.identifier.uri | https://hdl.handle.net/1822/70432 | - |
dc.description.abstract | Hemorheological alterations in the majority of metabolic diseases are always connected with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell aggregation enhancement, and reduction of the red blood cells (RBCs) deformability. Thus, the visualizations and measurements of blood cells deformability flowing in microfluidic devices (point-of-care devices) can provide vital information to diagnose early symptoms of blood diseases and consequently to be used as a fast clinical tool for early detection of biomarkers. For instance, RBCs rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, among other blood diseases. In order to better understand the blood cells behavior in microfluidic devices, rheological properties analysis is gaining interest by the biomedical committee, since it is strongly dependent on the interactions and mechanical cells proprieties. In addition, the development of blood analogue fluids capable of reproducing the rheological properties of blood and mimic the RBCs behavior at in vitro conditions is crucial for the design, performance and optimization of the microfluidic devices frequently used for personalized medicine. By combining the unique features of the hemorheology and microfluidic technology for single-cell analysis, valuable advances in personalized medicine for new treatments and diagnosis approach can be achieved. | por |
dc.description.sponsorship | This project has been funded by Portuguese national funds of FCT/MCTES (PIDDAC) through the base funding from the following research unit: UIDB/04077/2020, UIDB/00319/2020 and UIDB/00532/2020. The authors are also grateful for the partial funding of FCT through the projects NORTE-01-0145-FEDER-029394, NORTE-01-0145-FEDER-030171, funded by COMPETE2020, NORTE2020, PORTUGAL2020, and FEDER. | por |
dc.description.sponsorship | Diana Pinho acknowledges the PhD scholarship SFRH/BD/89077/2012 attributed by FCT. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | UIDB/04077/2020 | por |
dc.relation | UIDB/00319/2020 | por |
dc.relation | UIDB/00532/2020 | por |
dc.relation | NORTE-01-0145-FEDER-029394 | por |
dc.relation | NORTE-01-0145-FEDER-030171 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PT | por |
dc.rights | openAccess | por |
dc.subject | Hemorheology | por |
dc.subject | Blood diseases | por |
dc.subject | Microfluidics | por |
dc.subject | Single-cell analysis | por |
dc.subject | Red blood cells deformability | por |
dc.subject | Blood analogues | por |
dc.title | Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: a personalized medicine perspective | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2075-4426/10/4/249 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 18 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2021-02-25T09:34:14Z | - |
dc.identifier.doi | 10.3390/jpm10040249 | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 8968 | - |
sdum.journal | Journal of Personalized Medicine | por |
Aparece nas coleções: | CAlg - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jpm-10-00249.pdf | 4,47 MB | Adobe PDF | Ver/Abrir |