Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/69518
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Castro, N. | por |
dc.contributor.author | Ribeiro, Sylvie Oliveira | por |
dc.contributor.author | Fernandes, M. M. | por |
dc.contributor.author | Ribeiro, C. | por |
dc.contributor.author | Cardoso, V. | por |
dc.contributor.author | Correia, V. | por |
dc.contributor.author | Minguez, R. | por |
dc.contributor.author | Lanceros-Méndez, S. | por |
dc.date.accessioned | 2021-01-21T11:20:48Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | Castro, N., Ribeiro, S., Fernandes, M. M., Ribeiro, C., et. al.(2020). Physically Active Bioreactors for Tissue Engineering Applications. Advanced Biosystems, 4(10), 2000125. | por |
dc.identifier.uri | https://hdl.handle.net/1822/69518 | - |
dc.description.abstract | Tissue engineering (TE) is a strongly expanding research area. TE approaches require biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the natural tissue microenvironment. Also, the extracellular matrix serves as a structural base for cells and as a source of growth factors and biophysical cues. The 3D characteristics of the microenvironment is one of the most recognized key factors for obtaining specific cell responses in vivo, being the physical cues increasingly investigated. Supporting those advances is the progress of smart and multifunctional materials design, whose properties improve the cell behavior control through the possibility of providing specific chemical and physical stimuli to the cellular environment. In this sense, a varying set of bioreactors that properly stimulate those materials and cells in vitro, creating an appropriate biomimetic microenvironment, is developed to obtain active bioreactors. This review provides a comprehensive overview on the important microenvironments of different cells and tissues, the smart materials type used for providing such microenvironments and the specific bioreactor technologies that allow subjecting the cells/tissues to the required biomimetic biochemical and biophysical cues. Further, it is shown that microfluidic bioreactors represent a growing and interesting field that hold great promise for achieving suitable TE strategies | por |
dc.description.sponsorship | N.C. and S.R. contributed equally to this work. This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2020, UID/EEA/04436/2020 and projects PTDC/BTM-MAT/28237/2017 and PTDC/EMD-EMD/28159/2017. The authors also thank the FCT for the SFRH/BD/111478/2015 (S.R.), SFRH/BPD/121464/2016 (M.M.F.) grant. The authors acknowledge funding by the Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033 and from the Basque Government Industry and Education Department under the ELKARTEK, HAZITEK and PIBA (PIBA-2018-06) programs, respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.relation | UID/FIS/04650/2020 | - |
dc.relation | UID/EEA/04436/2020 | - |
dc.relation | PTDC/BTM-MAT/28237/2017 | - |
dc.relation | PTDC/EMD-EMD/28159/2017 | - |
dc.relation | SFRH/BD/111478/2015 | - |
dc.relation | SFRH/BPD/121464/2016 | - |
dc.rights | restrictedAccess | por |
dc.subject | Cell microenvironment | por |
dc.subject | Smart materials | por |
dc.subject | Bioreactors | por |
dc.subject | Microfluidic | por |
dc.subject | Physical stimuli | por |
dc.title | Physically active bioreactors for tissue engineering applications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/adbi.202000125 | por |
oaire.citationIssue | 10 | por |
oaire.citationVolume | 4 | por |
dc.identifier.eissn | 2366-7478 | - |
dc.identifier.doi | 10.1002/adbi.202000125 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Engenharia e Tecnologia::Biotecnologia Industrial | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Biosystems | por |
oaire.version | AO | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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45.pdf Acesso restrito! | 1,72 MB | Adobe PDF | Ver/Abrir |