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https://hdl.handle.net/1822/67425
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Martin, Constance J. | por |
dc.contributor.author | Booty, Matthew G. | por |
dc.contributor.author | Rosebrock, Tracy R. | por |
dc.contributor.author | Nunes-Alves, Cláudio | por |
dc.contributor.author | Desjardins, Danielle M. | por |
dc.contributor.author | Keren, Iris | por |
dc.contributor.author | Fortune, Sarah M. | por |
dc.contributor.author | Remold, Heinz G. | por |
dc.contributor.author | Behar, Samuel M. | por |
dc.date.accessioned | 2020-10-09T09:41:54Z | - |
dc.date.available | 2020-10-09T09:41:54Z | - |
dc.date.issued | 2012-09-13 | - |
dc.identifier.citation | Martin, C. J., Booty, M. G., Rosebrock, T. R., Nunes-Alves, C., Desjardins, D. M., et. al.(2012). Efferocytosis is an innate antibacterial mechanism. Cell host & microbe, 12(3), 289-300 | por |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67425 | - |
dc.description.abstract | Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis of M. tuberculosis-infected macrophages is associated with reduced bacterial growth, the bacteria are relatively resistant to other forms of death, leaving the mechanism underlying this observation unresolved. We find that after apoptosis, M. tuberculosis-infected macrophages are rapidly taken up by uninfected macrophages through efferocytosis, a dedicated apoptotic cell engulfment process. Efferocytosis of M. tuberculosis sequestered within an apoptotic macrophage further compartmentalizes the bacterium and delivers it along with the apoptotic cell debris to the lysosomal compartment. M. tuberculosis is killed only after efferocytosis, indicating that apoptosis itself is not intrinsically bactericidal but requires subsequent phagocytic uptake and lysosomal fusion of the apoptotic body harboring the bacterium. While efferocytosis is recognized as a constitutive housekeeping function of macrophages, these data indicate that it can also function as an antimicrobial effector mechanism. | por |
dc.description.sponsorship | Behar, Fortune, and Remold labs for reagents, helpful discussion, and insights. TIM4-blocking antibodies were a generous gift of Vijay Kuchroo. Members of the Harvard Electron Microscopy Core Facility helped in the preparation, staining, and operation of the electron microscope. The Small Animal Biocontainment (ABC) Suite is supported by CFAR 5P30AI060354. T.R.R and S.M.F were supported by CFAR 5P30AI060354, DP2-0d001378, and T32-AI07387. C.N.A. is the recipient of a fellowship from FCT. S.M.B and H.G.R. were supported by R56AI084161 and R01AI072143. | por |
dc.language.iso | eng | por |
dc.publisher | Cell Press | por |
dc.rights | openAccess | por |
dc.subject | Animals | por |
dc.subject | Cells, Cultured | por |
dc.subject | Immune Evasion | por |
dc.subject | Lysosomes | por |
dc.subject | Macrophages | por |
dc.subject | Mice | por |
dc.subject | Mice, Inbred C57BL | por |
dc.subject | Microbial Viability | por |
dc.subject | Microscopy, Electron, Transmission | por |
dc.subject | Microscopy, Fluorescence | por |
dc.subject | Mycobacterium tuberculosis | por |
dc.subject | Apoptosis | por |
dc.subject | Phagocytosis | por |
dc.title | Efferocytosis is an innate antibacterial mechanism | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1931312812002429 | por |
oaire.citationStartPage | 289 | por |
oaire.citationEndPage | 300 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 12 | por |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.doi | 10.1016/j.chom.2012.06.010 | por |
dc.identifier.pmid | 22980326 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cell Host & Microbe | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Jmartin-2012-Efferocytosis-is-an-innate-antibact.pdf | 1,15 MB | Adobe PDF | Ver/Abrir |