Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66146
Título: | Is the retinol-binding protein 4 a possible risk factor for cardiovascular diseases in obesity? |
Autor(es): | Rychter, Anna Maria Skrzypczak-Zielinska, Marzena Zielinska, Aleksandra Eder, Piotr Souto, Eliana B. Zawada, Agnieszka Ratajczak, Alicja Ewa Dobrowolska, Agnieszka Krela-Kazmierczak, Iwona |
Palavras-chave: | atherosclerosis RBP4 cardiovascular disease obesity metabolic syndrome lipoprotein metabolism |
Data: | 23-Jul-2020 |
Editora: | MDPI Publishing |
Revista: | International Journal of Molecular Sciences |
Citação: | Rychter, Anna Maria; Skrzypczak-Zielinska, Marzena; Zielinska, Aleksandra; Eder, Piotr; Souto, Eliana; Zawada, Agnieszka; Ratajczak, Alicja Ewa; Dobrowolska, Agnieszka; Krela-Kazmierczak, Iwona, Is the retinol-binding protein 4 a possible risk factor for cardiovascular diseases in obesity?. International Journal of Molecular Sciences, 21(15), 5229, 2020 |
Resumo(s): | Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the RBP4 gene polymorphisms essential from a cardiovascular perspective. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66146 |
ISBN: | 1424-6783 |
DOI: | 10.3390/ijms21155229 |
ISSN: | 1422-0067 |
e-ISSN: | 1661-6596 |
Versão da editora: | https://www.mdpi.com/1422-0067/21/15/5229 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53831_1.pdf | 1,74 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons