Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65537
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Andrade, Luciana Nalone | por |
dc.contributor.author | Marques, Conrado | por |
dc.contributor.author | Barbosa, Thallysson | por |
dc.contributor.author | Santos, Rafael | por |
dc.contributor.author | Chaud, Marco Vinícius | por |
dc.contributor.author | Ferreira da Silva, Classius | por |
dc.contributor.author | Corrêa, Cristiane Bani | por |
dc.contributor.author | Amaral, Ricardo Guimarães | por |
dc.contributor.author | de Souza Nunes, Rogéria | por |
dc.contributor.author | Gonsalves, Joyce Kelly M. C. | por |
dc.contributor.author | Allegretti, Silmara | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Severino, Patrícia | por |
dc.date.accessioned | 2020-05-31T13:37:09Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | Andrade, Luciana Nalone; Marques, Conrado; Barbosa, Thallysson; Santos, Rafael; Chaud, Marco Vinícius; Ferreira da Silva, Classius; Corrêa, Cristiane Bani; Amaral, Ricardo Guimarães; de Souza Nunes, Rogéria; Gonsalves, Joyce Kelly M. C.; Allegretti, Silmara; Souto, Eliana; Severino, Patrícia, Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical characterization, release profile, cytotoxicity and in vitro activity against Schistosoma mansoni. Journal of Drug Delivery Science and Technology, 58(101784), 2020 | por |
dc.identifier.issn | 1773-2247 | por |
dc.identifier.uri | https://hdl.handle.net/1822/65537 | - |
dc.description.abstract | Praziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SLN were produced by hot high shear homogenization. The obtained SLN exhibited a mean size of 300nm, with a polydispersity index of 0.20, zeta potential of-28mV and encapsulation efficiency of 92.31%. Thermal analysis demonstrated that the production process reduced the lipid crystallinity of the SLN matrices, which displayed a spherical morphology by scanning electron microscopy (SEM). The mathematical fitting of the release profile demonstrated that PZQ followed the Weibull model whereas PZQ-loaded SLN the Peppas model. PZQ-loaded SLN were more effective in inducing S. mansoni death than PZQ alone. The increased drug solubility did not exhibit toxicity against human fibroblast cell lines (L929). PZQ-loaded SLN demonstrated great parasiticidal properties, being an improved alternative to the classical treatment of schistosomiasis. | por |
dc.description.sponsorship | The authors wish to acknowledge Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, #443238/2014-6, #470388/2014-5). EBS wishes to acknowledge the financial support received from Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the projects M-ERA-NET0004/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Solid lipid nanoparticles | por |
dc.subject | Praziquantel | por |
dc.subject | Helminthiases | por |
dc.subject | Schistosoma mansoni | por |
dc.title | Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical characterization, release profile, cytotoxicity and in vitro activity against Schistosoma mansoni | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.journals.elsevier.com/journal-of-drug-delivery-science-and-technology | por |
dc.comments | CEB53708 | por |
oaire.citationVolume | 58 | por |
dc.date.updated | 2020-05-30T13:06:00Z | - |
dc.identifier.doi | 10.1016/j.jddst.2020.101784 | por |
dc.date.embargo | 10000-01-01 | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Drug Delivery Science and Technology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_53708_1.pdf Acesso restrito! | 2,5 MB | Adobe PDF | Ver/Abrir |