Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65375
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Blanco, Guillermo | por |
dc.contributor.author | Ruiz, Lorena | por |
dc.contributor.author | Tamés, Hector | por |
dc.contributor.author | Ruas-Madiedo, Patricia | por |
dc.contributor.author | Fdez-Riverola, Florentino | por |
dc.contributor.author | Sánchez, Borja | por |
dc.contributor.author | Lourenço, Anália | por |
dc.contributor.author | Margolles, Abelardo | por |
dc.date.accessioned | 2020-05-16T13:29:05Z | - |
dc.date.available | 2020-05-16T13:29:05Z | - |
dc.date.issued | 2020-05-13 | - |
dc.identifier.citation | Blanco, Guillermo; Ruiz, Lorena; Tamés, Hector; Ruas-Madiedo, Patricia; Fdez-Riverola, Florentino; Sánchez, Borja; Lourenço, Anália; Margolles, Abelardo, Revisiting the metabolic capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a glycoside hydrolase perspective. Microorganisms, 8(5), 723, 2020 | por |
dc.identifier.uri | https://hdl.handle.net/1822/65375 | - |
dc.description.abstract | Bifidobacteria are among the most abundant microorganisms inhabiting the intestine of humans and many animals. Within the genus Bifidobacterium, several beneficial effects have been attributed to strains belonging to the subspecies Bifidobacterium longum subsp. longum and Bifidobacterium longum subsp. infantis, which are often found in infants and adults. The increasing numbers of sequenced genomes belonging to these two subspecies, and the availability of novel computational tools focused on predicting glycolytic abilities, with the aim of understanding the capabilities of degrading specific carbohydrates, allowed us to depict the potential glycoside hydrolases (GH) of these bacteria, with a focus on those GH profiles that differ in the two subspecies. We performed an in silico examination of 188 sequenced B. longum genomes and depicted the commonly present and strain-specific GHs and GH families among representatives of this species. Additionally, GH profiling, genome-based and 16S rRNA-based clustering analyses showed that the subspecies assignment of some strains does not properly match with their genetic background. Furthermore, the analysis of the potential GH component allowed the distinction of clear GH patterns. Some of the GH activities, and their link with the two subspecies under study, are further discussed. Overall, our in silico analysis poses some questions about the suitability of considering the GH activities of B. longum subsp. longum and B. longum subsp. infantis to gain insight into the characterization and classification of these two subspecies with probiotic interest. | por |
dc.description.sponsorship | The research included in the present work was funded by the grants AGL2016-78311-R (funded by AEI/FEDER, UE), RTI2018-095021-J-I00 (funded by MCIU/AEI/FEDER, UE), and IDI/2018/000236 (funded by PCTI Gobierno del Principado de Asturias/FEDER, UE). This study was supported by the Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia) under the scope of the strategic funding of ED431C2018/55-GRC Competitive Reference Group, the “Centro singular de investigación de Galicia” (accreditation 2019-2022) and the European Union (European Regional Development Fund—ERDF)-Ref. ED431G2019/06, and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI Publishing | por |
dc.relation | UIDB/04469/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Bifidobacterium | por |
dc.subject | longum | por |
dc.subject | infantis | por |
dc.subject | carbohydrates | por |
dc.subject | glycoside hydrolases | por |
dc.subject | computational screening | por |
dc.title | Revisiting the metabolic capabilities of Bifidobacterium longum susbp. longum and Bifidobacterium longum subsp. infantis from a glycoside hydrolase perspective | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2076-2607/8/5/723 | por |
dc.comments | CEB53710 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2020-05-16T12:40:12Z | - |
dc.identifier.eissn | 2076-2607 | por |
dc.identifier.doi | 10.3390/microorganisms8050723 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Microorganisms | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53710_1.pdf | 2,78 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons