Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/64327
Título: | Key production parameters for the development of solid lipid nanoparticles by high shear homogenization |
Autor(es): | Souto, Eliana B. Doktorovova, Slavomira Zielinska, Aleksandra Silva, Amélia M. |
Palavras-chave: | Solid lipid nanoparticles high shear homogenization high-pressure homogenization rotor stator cetyl trimethylammonium bromide |
Data: | 8-Ago-2019 |
Editora: | Marcel Dekker Inc. |
Revista: | Pharmaceutical Development and Technology |
Citação: | Souto, Eliana; Doktorovova, Slavomira; Zielinska, Aleksandra; Silva, Amélia M., Key production parameters for the development of solid lipid nanoparticles by high shear homogenization. Pharmaceutical Development and Technology, 24(9), 1181-1185, 2019 |
Resumo(s): | In this work, we report the development and optimization of solid lipid nanoparticles (SLN) production by a simple, fast, and cost-effective high shear homogenization process. A screening of several solid lipids (Compritol 888 ATO, Precirol ATO 5, Cetyl Palmitate, Dynasan 118, Imwitor 900K, Stearic acid) has been carried out in combination with Poloxamer 188 as the selected surfactant, based on the mean particle size and polydispersity index. The improvement of the physical stability of the SLN dispersions was achieved by the use of a cationic lipid (cetyl trimethylammonium bromide) reaching zeta potential values above +60 mV. Combining the optimized speed and time of shear, monodispersed SLN (PdI < 0.25) under the nanometer range could be produced. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/64327 |
DOI: | 10.1080/10837450.2019.1647235 |
ISSN: | 1083-7450 |
e-ISSN: | 1097-9867 |
Versão da editora: | https://www.tandfonline.com/loi/iphd20 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
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document_51954_1.pdf Acesso restrito! | 192,31 kB | Adobe PDF | Ver/Abrir |