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https://hdl.handle.net/1822/62685
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Campo DC | Valor | Idioma |
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dc.contributor.author | Carbone, C. | por |
dc.contributor.author | Fuochi, V. | por |
dc.contributor.author | Zielinska, A. | por |
dc.contributor.author | Musumeci, T. | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Bonaccorso, A. | por |
dc.contributor.author | Puglia, C. | por |
dc.contributor.author | Petronio, G. Petronio | por |
dc.contributor.author | Furneri, P. M. | por |
dc.date.accessioned | 2019-12-16T15:16:02Z | - |
dc.date.available | 2019-12-16T15:16:02Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Carbone, C.; Fuochi, V.; Zielinska, A.; Musumeci, T.; Souto, Eliana; Bonaccorso, A.; Puglia, C.; Petronio, G. Petronio; Furneri, P. M., Dual-drugs delivery in Solid Lipid Nanoparticles for the treatment of Candida albicans mycosis. Colloids and Surfaces B- Biointerfaces, 186(110705), 2020 | por |
dc.identifier.issn | 0927-7765 | por |
dc.identifier.uri | https://hdl.handle.net/1822/62685 | - |
dc.description | Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.colsurfb.2019.110705. | por |
dc.description.abstract | Nowadays, a combinatorial drug delivery system that simultaneously transports two or more drugs to the targeted site in a human body, also recognized as a dual-drugs delivery system, represents a promising strategy to overcome drug resistance. Solid lipid nanoparticles loaded with clotrimazole (CLZ) and alphalipolic acid (ALA), considered as an effective agent in the reduction of reactive oxygen species, can enhance anti-infective immunity being proposed as a non-toxic and mainly non-allergic dual-drugs delivery system. In this study, uncoated and cationic CLZ-ALA-loaded SLN were prepared and compared. Suspensions with a narrow size distribution of particles of mean size below 150?nm were obtained, having slight negative or highly positive zeta potential values, due to the presence of the cationic lipid, which also increased nanoparticles stability, as confirmed by Turbiscan® results. Calorimetric studies confirmed the rationale of separately delivering the two drugs in a dual-delivery system. Furthermore, they confirmed the formation of SLN, without significant variation in presence of the cationic lipid. In vitro release studies showed a prolonged drug release without the occurrence of any burst effect. In vitro studies performed on 25 strains of Candida albicans showed the antimicrobial drug activity was not altered when it was loaded into lipid nanoparticles. The study has proved the successfully encapsulation of CLZ and ALA in solid lipid nanoparticles that may represent a promising strategy to combine ALA protective effect in the treatment with CLZ. | por |
dc.description.sponsorship | This research was financed by Research Funding for University of Catania, under Project Piano per la Ricerca 2016-2018 – Linea Di Intervento2“DotazioneOrdinaria”cod.57722172106. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | SLN | por |
dc.subject | clotrimazole | por |
dc.subject | alpha-lipolic acid | por |
dc.subject | combinatorial drug delivery system | por |
dc.subject | dual-drug delivery system | por |
dc.subject | PIT method | por |
dc.subject | antifungal activity | por |
dc.title | Dual-drugs delivery in Solid Lipid Nanoparticles for the treatment of Candida albicans mycosis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/ | por |
dc.comments | CEB52265 | por |
oaire.citationVolume | 186 | por |
dc.date.updated | 2019-12-14T16:31:01Z | - |
dc.identifier.doi | 10.1016/j.colsurfb.2019.110705 | por |
dc.identifier.pmid | 31830707 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Colloids and Surfaces B: Biointerfaces | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_52265_1.pdf | 1,99 MB | Adobe PDF | Ver/Abrir |