Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62598
Título: | Label-free quantum dot conjugates for human protein IL-2 based on molecularly imprinted polymers |
Autor(es): | Piloto, Margarida Ribeiro, David S. M. Rodrigues, S. Sofia M. Santos, João L. M. Sales, M. G. F. |
Palavras-chave: | Quantum dots molecularly imprinted polymer conjugated-QDs protein interleukin-2 cancer biomarker |
Data: | Fev-2020 |
Editora: | Elsevier 1 |
Revista: | Sensors and Actuators B: Chemical |
Citação: | Piloto, Margarida; David S. M. Ribeiro; S. Sofia M. Rodrigues; João L. M. Santos; Sales, M. G. F., Label-free quantum dot conjugates for human protein IL-2 based on molecularly imprinted polymers. Sensors and Actuators B-Chemical, 304(127343), 2020 |
Resumo(s): | Herein, the development of a fluorescent-based sensor by combining quantum dots (QDs) with molecularly-imprinted technology (MIP), intensively optimized to generate exceptional operating features is presented. This sensor is designed to target human interleukin-2 (IL-2) in synthetic human serum. IL-2 is a regulatory protein released as a triggered response from the immune system towards an inflammation. For this purpose, cadmium telluride (CdTe) QDs are prepared with 3-mercaptopropionic acid (MPA) and modified afterwards to produce an IL-2 imprinted polymer with methacrylic acid and N,N´-methylenebis(acrylamide), upon removal of the template under optimized conditions. During IL-2 rebinding, the fluorescence intensity of CdTe |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62598 |
DOI: | 10.1016/j.snb.2019.127343 |
ISSN: | 0925-4005 |
Versão da editora: | https://www.journals.elsevier.com/sensors-and-actuators-b-chemical |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_52177_1.pdf | 4,04 MB | Adobe PDF | Ver/Abrir |