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https://hdl.handle.net/1822/62352
Título: | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
Autor(es): | Lord, Louis-David Expert, Paul Atasoy, Selen Roseman, Leor Rapuano, Kristina Lambiotte, Renaud Nutt, David J. Deco, Gustavo Carhart-Harris, Robin L. Kringelbach, Morten L. Cabral, Joana |
Data: | 2019 |
Editora: | Elsevier 1 |
Revista: | Neuroimage |
Citação: | Lord, L. D., Expert, P., Atasoy, S., Roseman, L., Rapuano, K.,et. al.(2019). Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin. NeuroImage, 199, 127-142. |
Resumo(s): | Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in "magic mushrooms". We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session. Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62352 |
DOI: | 10.1016/j.neuroimage.2019.05.060 |
ISSN: | 1053-8119 |
e-ISSN: | 1095-9572 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1053811919304525 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S1053811919304525-main.pdf | 5,95 MB | Adobe PDF | Ver/Abrir |