Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62321
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Deco, Gustavo | por |
dc.contributor.author | Cruzat, Josephine | por |
dc.contributor.author | Cabral, Joana | por |
dc.contributor.author | Tagliazucchi, Enzo | por |
dc.contributor.author | Laufs, Helmut | por |
dc.contributor.author | Logothetis, Nikos K. | por |
dc.contributor.author | Kringelbach, Morten L. | por |
dc.date.accessioned | 2019-11-21T17:30:28Z | - |
dc.date.available | 2020-03-03T07:00:20Z | - |
dc.date.issued | 2019-09-03 | - |
dc.identifier.citation | Deco, G., Cruzat, J., Cabral, J., Tagliazucchi, E., Laufs, H., Logothetis, N. K., & Kringelbach, M. L. (2019). Awakening: Predicting external stimulation to force transitions between different brain states. Proceedings of the National Academy of Sciences, 116(36), 18088-18097. | por |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62321 | - |
dc.description.abstract | A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires a quantitative and robust definition of a brain state, which has so far proven elusive. Here, we provide such a definition, which, together with whole-brain modeling, permits the systematic study in silico of how simulated brain stimulation can force transitions between different brain states in humans. Specifically, we use a unique neuroimaging dataset of human sleep to systematically investigate where to stimulate the brain to force an awakening of the human sleeping brain and vice versa. We show where this is possible using a definition of a brain state as an ensemble of "metastable substates," each with a probabilistic stability and occurrence frequency fitted by a generative whole-brain model, fine-tuned on the basis of the effective connectivity. Given the biophysical limitations of direct electrical stimulation (DES) of microcircuits, this opens exciting possibilities for discovering stimulation targets and selecting connectivity patterns that can ensure propagation of DES-induced neural excitation, potentially making it possible to create awakenings from complex cases of brain injury. | por |
dc.description.sponsorship | Spanish Research Project PSI2016-75688-P (Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union); by the European Union’s Horizon 2020 Re-search and Innovation Programme under Grant Agreements 720270 (Hu-man Brain Project [HBP] SGA1) and 785907 (HBP SGA2); and by the CatalanAgency for Management of University and Research Grants Programme 2017 SGR 1545. J. Cabral is supported by Portuguese Foundation for Sci-ence and Technology CEECIND/03325/2017, Portugal. M.L.K. is supportedby the European Research Council Consolidator Grant: CAREGIVING (615539) and Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). | por |
dc.language.iso | eng | por |
dc.publisher | National Academy of Sciences | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/720270/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/785907/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/615539/EU | - |
dc.rights | openAccess | por |
dc.subject | Brain states | por |
dc.subject | Metastates | por |
dc.subject | Electrical stimulation | por |
dc.subject | Computational neuroscience | por |
dc.subject | Modeling | por |
dc.title | Awakening: Predicting external stimulation to force transitions between different brain states | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.pnas.org/content/116/36/18088.short | por |
oaire.citationStartPage | 18088 | por |
oaire.citationEndPage | 18097 | por |
oaire.citationIssue | 36 | por |
oaire.citationVolume | 116 | por |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.doi | 10.1073/pnas.1905534116 | por |
dc.identifier.pmid | 31427539 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Proceedings of the National Academy of Sciences | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Deco_PNAS_2019.pdf | 2,3 MB | Adobe PDF | Ver/Abrir |