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https://hdl.handle.net/1822/62303
Título: | Amino acid metabolism as drug target in autoimmune diseases |
Autor(es): | Mondanelli, Giada Iacono, Alberta Carvalho, Agostinho Orabona, Ciriana Volpi, Claudia Pallotta, Maria T. Matino, Davide Esposito, Susanna Grohmann, Ursula |
Palavras-chave: | Amino Acids Animals Arginase 1 Autoimmune Diseases Humans Immunosuppressive Agents Indoleamine 2,3-dioxygenase 1 Metabolic Networks and Pathways Molecular Targeted Therapy Tryptophan Arginine metabolism Host genetics Immune regulation Tryptophan metabolism |
Data: | Abr-2019 |
Editora: | Elsevier 1 |
Revista: | Autoimmunity Reviews |
Resumo(s): | In mammals, amino acid metabolism has evolved to control immune responses. Autoimmune diseases are heterogeneous conditions that involve the breakdown of tolerogenic circuitries and consequent activation of autoreactive immune cells. Therefore, critical enzymes along amino acid degradative pathways may be hijacked to keep in check autoimmunity. We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins. At variance with neoplastic contexts, in which it is known to act as a pure immunosuppressive molecule, ARG1 exhibited a protective or pathogenetic profile, depending on the disease. In contrast, in several autoimmune conditions, the bulk of data indicated that drugs capable of potentiating IDO1 expression and activity may represent valuable therapeutic tools and that IDO1-based immunotherapeutic protocols could be more effective if tailored to the genetic profile of individual patients. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62303 |
DOI: | 10.1016/j.autrev.2019.02.004 |
ISSN: | 1568-9972 |
e-ISSN: | 1873-0183 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Mondanelli G et al. Autoimmun Rev.pdf | 1,07 MB | Adobe PDF | Ver/Abrir |