Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62084
Título: | Intra-axonal protein synthesis in development and beyond |
Autor(es): | Batista, Andreia Filipa Rodrigues Hengst, Ulrich |
Palavras-chave: | Animals Axons Humans Nerve Regeneration Nerve Tissue Proteins Neurons RNA, Messenger Axonal translation mRNA Axon growth/branching Nerve injury Neurodegeneration Synapse formation |
Data: | Dez-2016 |
Editora: | Elsevier 1 |
Revista: | International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience |
Citação: | Batista, A. F. R., & Hengst, U. (2016). Intra-axonal protein synthesis in development and beyond. International Journal of Developmental Neuroscience, 55, 140-149. |
Resumo(s): | Proteins can be locally produced in the periphery of a cell, allowing a rapid and spatially precise response to the changes in its environment. This process is especially relevant in highly polarized and morphologically complex cells such as neurons. The study of local translation in axons has evolved from being primarily focused on developing axons, to the notion that also mature axons can produce proteins. Axonal translation has been implied in several physiological and pathological conditions, and in all cases it shares common molecular actors and pathways as well as regulatory mechanisms. Here, we review the main findings in these fields, and attempt to highlight shared principles. |
Tipo: | Artigo |
Descrição: | Author Manuscript |
URI: | https://hdl.handle.net/1822/62084 |
DOI: | 10.1016/j.ijdevneu.2016.03.004 |
ISSN: | 0736-5748 |
e-ISSN: | 1873-474X |
Versão da editora: | https://repositorium.sdum.uminho.pt/retrieve/41831f48-3a39-4eb7-b679-973a8271a5e3/nihms770831.pdf |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nihms770831.pdf Acesso restrito! | 621,03 kB | Adobe PDF | Ver/Abrir |