Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62007
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Cardoso, Olívia | por |
dc.contributor.author | Puga, Sónia Andreia Silva | por |
dc.contributor.author | Brandão, Fátima | por |
dc.contributor.author | Canário, João | por |
dc.contributor.author | O'Driscoll, Nelson J. | por |
dc.contributor.author | Santos, Maria Ana | por |
dc.contributor.author | Pacheco, Mário | por |
dc.contributor.author | Pereira, Patrícia | por |
dc.date.accessioned | 2019-11-11T11:01:55Z | - |
dc.date.issued | 2017-09-15 | - |
dc.identifier.issn | 0025-326X | - |
dc.identifier.uri | https://hdl.handle.net/1822/62007 | - |
dc.description.abstract | This study examines, for the first time, the neurotoxicity of Hg(II) and MeHg in fish (Diplodus sargus) in a time-course comparative perspective and considering realistic exposure levels and routes. Both forms followed an identical time-variation pattern of accumulation in the brain, but dietary MeHg was more efficiently transported to the brain. MeHg was substantially eliminated from the brain in 28days of depuration, which did not occur for Hg(II). Moreover, Hg(II) displayed a high neurotoxicity potential, as unveiled by the poor activation of brain antioxidant defenses and recurrent oxidative damage (as protein oxidation), while the opposite was recorded upon MeHg exposure. These results highlight the need to include Hg(II) in future environmental health assessment plans, preventing an underestimation of the risk for wild fish populations, which has probably been occurring due to the long-standing idea of the higher toxicity of MeHg in comparison with inorganic Hg forms. | por |
dc.description.sponsorship | Patrícia Pereira benefited from post-doctoral grant (SFRH/BPD/ 107718/2015) supported by “Fundação para a Ciência e a Tecnologia” (FCT). This work has been supported by the Research project financed by FCT PTDC/AAG-REC/2488/2012 (NEUTOXMER - Neurotoxicity of mercury in fish and association with morphofunctional brain alterations and behavior shifts), as well as by the Centre for Environmental and Marine Studies (CESAM). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Animals | por |
dc.subject | Brain | por |
dc.subject | Mercury | por |
dc.subject | Methylmercury Compounds | por |
dc.subject | Water Pollutants, Chemical | por |
dc.subject | Fishes | por |
dc.subject | Oxidative Stress | por |
dc.subject | Inorganic mercury | por |
dc.subject | Neurotoxicity | por |
dc.subject | Methylmercury | por |
dc.subject | Fish | por |
dc.title | Oxidative stress profiles in brain point out a higher susceptibility of fish to waterborne divalent mercury compared to dietary organic mercury | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 110 | por |
oaire.citationEndPage | 121 | por |
oaire.citationIssue | 1/2 | por |
oaire.citationVolume | 122 | por |
dc.identifier.eissn | 1879-3363 | - |
dc.identifier.doi | 10.1016/j.marpolbul.2017.06.029 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 28641884 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Marine Pollution Bulletin | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Cardoso-2017-Oxidative-stress-profiles-in-brain-.pdf Acesso restrito! | 1,53 MB | Adobe PDF | Ver/Abrir |