Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61730
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Ferreira, Jorge M. L. | por |
dc.contributor.author | Vieira, Vítor | por |
dc.contributor.author | Gomes, Jorge | por |
dc.contributor.author | Correia, Sara | por |
dc.contributor.author | Rocha, Miguel | por |
dc.date.accessioned | 2019-10-11T10:03:51Z | - |
dc.date.available | 2019-10-11T10:03:51Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Ferreira, Jorge; Vieira, Vítor; Gomes, Jorge; Correia, Sara; Rocha, Miguel, Troppo - A Python framework for the reconstruction of context-specific metabolic models. Advances in Intelligent Systems and Computing. Vol. 1005 (PACBB 2019), Springer, 146-153, 2020. | por |
dc.identifier.isbn | 9783030238728 | por |
dc.identifier.issn | 2194-5357 | por |
dc.identifier.uri | https://hdl.handle.net/1822/61730 | - |
dc.description.abstract | The surge in high-throughput technology availability for molecular biology has enabled the development of powerful predictive tools for use in many applications, including (but not limited to) the diagnosis and treatment of human diseases such as cancer. Genome-scale metabolic models have shown some promise in clearing a path towards precise and personalized medicine, although some challenges still persist. The integration of omics data and subsequent creation of context-specific models for specific cells/tissues still poses a significant hurdle, and most current tools for this purpose have been implemented using proprietary software. Here, we present a new software tool developed in Python, troppo - Tissue-specific RecOnstruction and Phenotype Prediction using Omics data, implementing a large variety of context-specific reconstruction algorithms. Our framework and workflow are modular, which facilitates the development of newer algorithms or omics data sources. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. The authors also thank the PhD scholarships funded by national funds through Fundacao para a Ciencia e Tecnologia, with references: SFRH/BD/133248/2017 (J.F.), SFRH/BD/118657/2016 (V.V.). | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.rights | openAccess | por |
dc.subject | Context-specific model reconstruction | por |
dc.subject | Tissue specific models | por |
dc.subject | Genome-scale metabolic models | por |
dc.subject | Omics data integration | por |
dc.title | Troppo - A Python framework for the reconstruction of context-specific metabolic models | por |
dc.type | conferencePaper | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.springer.com/series/11156 | por |
dc.comments | CEB51779 | por |
oaire.citationStartPage | 146 | por |
oaire.citationEndPage | 153 | por |
oaire.citationVolume | 1005 | por |
dc.date.updated | 2019-09-28T12:36:40Z | - |
dc.identifier.eissn | 2194-5365 | por |
dc.identifier.doi | 10.1007/978-3-030-23873-5_18 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advances in Intelligent Systems and Computing | por |
sdum.conferencePublication | PRACTICAL APPLICATIONS OF COMPUTATIONAL BIOLOGY AND BIOINFORMATICS | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51779_1.pdf | 242,48 kB | Adobe PDF | Ver/Abrir |