Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/61262
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gomes, Fernanda Isabel | por |
dc.contributor.author | Rodrigues, M. Elisa | por |
dc.contributor.author | Martins, Natália | por |
dc.contributor.author | Ferreira, Isabel C. F. R. | por |
dc.contributor.author | Henriques, Mariana | por |
dc.date.accessioned | 2019-09-02T09:26:28Z | - |
dc.date.available | 2019-09-02T09:26:28Z | - |
dc.date.issued | 2019-08-31 | - |
dc.identifier.citation | Gomes, Fernanda Isabel; Rodrigues, M. Elisa; Martins, Natália; Ferreira, Isabel C. F. R.; Henriques, Mariana, Phenolic plant extracts versus Penicillin g: in vitro susceptibility of Staphylococcus aureus isolated from bovine mastitis. Pharmaceuticals, 12(3), 128, 2019 | por |
dc.identifier.issn | 1424-8247 | por |
dc.identifier.uri | https://hdl.handle.net/1822/61262 | - |
dc.description.abstract | Antibiotics are the elective drugs in bovine mastitis (BM) treatment, despite their low rates of efficiency and effectiveness and increasing risk of pathogen resistance. In this sense, it is urgent to discover new and effective antimicrobial agents to apply in BM control and even treatment. Plant extracts have been widely recognized as a rich source of phytochemicals with antimicrobial potential. Thus, the present work aims to compare the bioactivity of Eucalyptus globulus and Juglans regia extracts against Staphylococcus aureus bovine mastitis strains with penicillin G. At non-toxic concentrations, E. globulus exerted a bacteriostatic effect in planktonic cells and J. regia had no antimicrobial activity. Penicillin G, at minimum inhibitory concentration (MIC), demonstrated bactericidal activity, but just for S. aureus 3, 5, 6 and ATCC 25923, while the other strains seem to have acquired resistance. On the other hand, E. globulus and penicillin G in combination demonstrated synergy, being the most effective approach against S. aureus 1, 2 and 4. Thus, penicillin alone and in combination with E. globulus or J. regia seems to be promissory strategies to control bovine mastitis infections. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) (grants number SFRH/BPD/84488/2012 and SFRH/BPD/95401/2013) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of the Norte2020 Programa Operacional Regional do Norte, as also Pest-OE/AGR/UI0690/2014 to CIMO. The authors also acknowledge Ana Maria Carvalho for the collection and identification of the wild samples, chemically characterized in previous studies. N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT–Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020—Programa Operacional Regional do Norte” (NORTE-01-0145-FEDER-000012). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F84488%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F95401%2F2013/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/135938/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147342/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | bovine mastitis | por |
dc.subject | Eucalyptus globulus Labill. | por |
dc.subject | Juglans regia L. | por |
dc.subject | penicillin G | por |
dc.subject | Staphylococcus aureus | por |
dc.title | Phenolic plant extracts versus Penicillin G: in vitro susceptibility of Staphylococcus aureus isolated from bovine mastitis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.comments | CEB51955 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2019-09-02T09:04:41Z | - |
dc.identifier.doi | 10.3390/ph12030128 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pharmaceuticals | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51955_1.pdf | 1,05 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons