Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60758
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Dias, Oscar | por |
dc.contributor.author | Saraiva, J. | por |
dc.contributor.author | Faria, Cristiana | por |
dc.contributor.author | Ramirez, Mario | por |
dc.contributor.author | Pinto, Francisco | por |
dc.contributor.author | Rocha, I. | por |
dc.date.accessioned | 2019-07-03T09:50:09Z | - |
dc.date.available | 2019-07-03T09:50:09Z | - |
dc.date.issued | 2019-06-25 | - |
dc.identifier.citation | Dias, Oscar; Saraiva, J.; Faria, Cristiana; Ramirez, Mario; Pinto, Francisco; Rocha, Isabel, iDS372, a phenotypically reconciled model for the metabolism of Streptococcus pneumoniae strain R6. Frontiers in Microbiology, 10(1283), 2019 | por |
dc.identifier.issn | 1664-302X | por |
dc.identifier.uri | https://hdl.handle.net/1822/60758 | - |
dc.description | The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb. 2019.01283/full#supplementary-material | por |
dc.description.abstract | A high-quality GSM model for Streptococcus pneumoniae R6 model strain (iDS372), comprising 372 genes and 529 reactions, was developed. The construction of this model involved performing a genome-wide reannotation to identify the metabolic capacity of the bacterium. A reaction representing the abstraction of the biomass composition was reconciled from several studies reported in the literature and previous models, and included in the model. The final model comprises two compartments and manifold automatically generated gene rules. The validation was performed with experimental data from recent studies, regarding the usability of carbon sources, the effect of the presence of oxygen and the requirement of amino acids for growth. This model can be used to better understand the metabolism of this major pathogen, provide clues regarding new drug targets and eventually design strategies for fighting infections by these bacteria. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional doNorte. This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreementno.686070. | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/686070/EU | por |
dc.rights | openAccess | por |
dc.subject | genome-scale metabolic model | por |
dc.subject | Streptococcus pneumoniae R6 | por |
dc.subject | metabolic reconstruction | por |
dc.subject | iDS372 | por |
dc.subject | avirulent | por |
dc.subject | phenotypical reconciliation | por |
dc.title | iDS372, a phenotypically reconciled model for the metabolism of Streptococcus pneumoniae strain R6 | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://journal.frontiersin.org/journal/microbiology | por |
dc.comments | CEB51774 | por |
oaire.citationIssue | JUN | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2019-06-29T11:15:33Z | - |
dc.identifier.doi | 10.3389/fmicb.2019.01283 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51774_1.pdf | 1,57 MB | Adobe PDF | Ver/Abrir |