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https://hdl.handle.net/1822/60420
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gaio, Vânia Silva | por |
dc.contributor.author | Cerca, Nuno | por |
dc.date.accessioned | 2019-05-28T14:02:55Z | - |
dc.date.available | 2019-05-28T14:02:55Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | Gaio, Vania; Cerca, Nuno, Cells released from S. epidermidis biofilms present increased antibiotic tolerance to multiple antibiotics. PeerJ, 7(e6884), 2019 | por |
dc.identifier.issn | 2167-8359 | por |
dc.identifier.uri | https://hdl.handle.net/1822/60420 | - |
dc.description.abstract | Biofilm released cells (Brc) are thought to present an intermediary phenotype between biofilm and planktonic cells and this has the potential of affecting their antimicrobial tolerance. Aim Compare the antimicrobial tolerance profiles of Brc, planktonic or biofilm cultures of S. epidermidis. Methodology Planktonic, biofilm cultures or Brc from 11 isolates were exposed to peak serum concentrations (PSC) of antibiotics. The antimicrobial killing effect in the three populations was determined by CFU. Results Increased Brc tolerance to vancomycin, teicoplanin, rifampicin, erythromycin, and tetracycline was confirmed in model strain 9142. Furthermore, significant differences in the susceptibility of Brc to vancomycin were further found in 10 other clinical isolates. Conclusions Brc from distinct clinical isolates presented a decreased susceptibility to most antibiotics tested and maintained that enhanced tolerance despite growing planktonically for up to 6 h. Our data suggest that Brc maintain the typical enhanced antibiotic tolerance of biofilm populations, further suggesting that addressing antimicrobial susceptibility in planktonic cultures might not reflect the full potential of biofilm-associated bacteria to survive therapy. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 and by BioTecNorte operation(NORTE-01-0145-FEDER-000004)fundedbyEuropeanRegionalDevelopment Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | por |
dc.language.iso | eng | por |
dc.publisher | PeerJ Inc | por |
dc.relation | UID/BIO/04469/2019 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Biofilm disassembly | por |
dc.subject | S. epidermidis | por |
dc.subject | Biofilm-released cells | por |
dc.subject | Antimicrobial tolerance | por |
dc.title | Cells released from S. epidermidis biofilms present increased antibiotic tolerance to multiple antibiotics | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://peerj.com/ | por |
dc.comments | CEB51723 | por |
oaire.citationIssue | e6884 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2019-05-19T16:50:47Z | - |
dc.identifier.doi | 10.7717/peerj.6884 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | PeerJ | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_51723_1.pdf | 380,24 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons