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https://hdl.handle.net/1822/60026
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Campo DC | Valor | Idioma |
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dc.contributor.author | Leroy, Felix | por |
dc.contributor.author | Park, Jung | por |
dc.contributor.author | Asok, Arun | por |
dc.contributor.author | Brann, David H | por |
dc.contributor.author | Meira, Torcato Duarte Novo | por |
dc.contributor.author | Boyle, Lara M | por |
dc.contributor.author | Buss, Eric W | por |
dc.contributor.author | Kandel, Eric R | por |
dc.contributor.author | Siegelbaum, Steven A | por |
dc.date.accessioned | 2019-04-12T15:54:33Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://hdl.handle.net/1822/60026 | - |
dc.description.abstract | Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Activation of the lateral septum by CA2 recruits a circuit that disinhibits a subnucleus of the ventromedial hypothalamus that is known to trigger attack. The social hormone arginine vasopressin enhances social aggression by acting on arginine vasopressin 1b receptors on CA2 presynaptic terminals in the lateral septum to facilitate excitatory synaptic transmission. In this manner, release of arginine vasopressin in the lateral septum, driven by an animal's internal state, may serve as a modulatory control that determines whether CA2 activity leads to declarative memory of a social encounter and/or promotes motivated social aggression. | por |
dc.description.sponsorship | We thank N. Renier, the Rockefeller imaging center and the laboratories of F. Polleux and T. Jessell for their help in creating Supplementary Video 1. We also thank R. Bruno, L. Herbaut and the members of the Siegelbaum laboratory for discussions. This work was supported by the R01 MH104602 and R01 MH106629 from NIH (S.A.S.), PD/BD/113700/2015 from the Portuguese Foundation for Science and Technology (T.M.), 5TL1TR001875-03 from NIH (E.W.B.) and the HHMI (E.R.K). | por |
dc.language.iso | eng | por |
dc.publisher | Nature Publishing Group | por |
dc.relation | PD/BD/113700/2015 | por |
dc.rights | restrictedAccess | por |
dc.title | A circuit from hippocampal CA2 to lateral septum disinhibits social aggression | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 213 | por |
oaire.citationEndPage | 218 | por |
oaire.citationIssue | 7735 | por |
oaire.citationVolume | 564 | por |
dc.identifier.doi | 10.1038/s41586-018-0772-0 | por |
dc.identifier.pmid | 30518859 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nature | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
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Ficheiro | Descrição | Tamanho | Formato | |
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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.pdf Acesso restrito! | 52,86 MB | Adobe PDF | Ver/Abrir |