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https://hdl.handle.net/1822/59546
Título: | In vitro SPF and photostability assays of emulsion containing nanoparticles with vegetable extracts rich in flavonoids |
Autor(es): | Cefali, Letícia Caramori Ataide, Janaína Artem Eberlin, Samara Gonçalves, Fernanda Cristina da Silva Fernandes, Ana Rita Marto, Joana Ribeiro, Helena Margarida Foglio, Mary Ann Mazzola, Priscila Gava Souto, Eliana B. |
Palavras-chave: | flavonoids nanoparticles permeation photostability rutin sunscreen |
Data: | 2019 |
Editora: | American Association of Pharmaceutical Scientists |
Revista: | AAPS PharmSciTech |
Citação: | Cefali, Letícia Caramori; Ataide, Janaína Artem; Eberlin, Samara; Gonçalves, Fernanda C. da Silva; Fernandes, Ana Rita; Marto, Joana; Ribeiro, Helena Margarida; Foglio, Mary Ann; Mazzola, Priscila Gava; Souto, Eliana, In vitro SPF and photostability assays of emulsion containing nanoparticles with vegetable extracts rich in flavonoids. AAPS PharmSciTech, 20(9), 2019 |
Resumo(s): | The aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L.) were produced and characterized for their morphology, mean particle size, zeta potential, and encapsulation efficiency. A final topical formulation was obtained by dispersing chitosan/TPP nanoparticles in an o/w emulsion. Results showed that nanoparticles dispersion exhibited yellowish color, spherical shape, and uniform appearance. Extract-loaded chitosan/TPP nanoparticles showed a mean particle size of 557.11±3.1 nm, polydispersity index of 0.39±0.27, zeta potential of +11.54±2.1 mV, and encapsulation efficiency of 75.89% of rutin. The recorded texture parameters confirm that the developed formulation is appropriate for skin application. The SPF obtained was 2.3±0.4, with a critical wavelength of 387.0 nm and 0.69 UVA/UVB ratio. The developed formulation exhibited photostability, allowing the release of flavonoids from nanoparticles while retaining rutin into the skin in a higher extension. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/59546 |
DOI: | 10.1208/s12249-018-1217-7 |
ISSN: | 1530-9932 |
e-ISSN: | 1522-1059 |
Versão da editora: | https://www.springer.com/biomed/pharmacology+%26+toxicology/journal/12249 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_49384_1.pdf Acesso restrito! | 653,07 kB | Adobe PDF | Ver/Abrir |