Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58938
Título: | Tandem palladium-catalyzed borylation and Suzuki coupling (BSC) to thienocarbazole precursors |
Autor(es): | Ferreira, Isabel C. F. R. Queiroz, Maria João R. P. Kirsch, Gilbert |
Palavras-chave: | palladium borylation Suzuki coupling 2-methyl-2 '-nitro biaryls benzo[b]thiophenes |
Data: | 2003 |
Editora: | Elsevier Ltd |
Revista: | Tetrahedron Letters |
Resumo(s): | Substituted 2-methyl-2 -nitro diaryl compounds in the benzo[b]thiophene series were prepared by palladium-catalyzed, two-step, one-pot borylation/Suzuki coupling (BSC) reaction in good to high yields. The borylation reaction was performed on methylated 6-bromobenzo[b]thiophenes using pinacolborane and was followed by in situ Suzuki coupling with substituted (CF3, OMe) 2-bromonitrobenzenes. The compounds obtained were cyclized to the corresponding ring A substituted thienocarbazoles which can have biological activity or/and be used as biomarkers due to their fluorescence properties and possible DNA intercalation. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58938 |
DOI: | 10.1016/S0040-4039(03)00952-3 |
ISSN: | 0040-4039 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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TETLET03.pdf | 119,38 kB | Adobe PDF | Ver/Abrir |