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https://hdl.handle.net/1822/58718
Título: | Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever |
Autor(es): | Abreu-Mota, Tiago Hagen, Katie R. Cooper, Kurt Jahrling, Peter B. Tan, Gene Wirblich, Christoph Johnson, Reed F. Schnell, Matthias J. |
Palavras-chave: | 3T3 Cells Animals Antibodies, Neutralizing Antibodies, Viral Antibody-Dependent Cell Cytotoxicity Cell Membrane Genetic Vectors Glucosides Glycoproteins Guinea Pigs Immunity, Humoral Immunization Immunoglobulin G Lassa Fever Lassa virus Lipid A Macrophages Mice Mice, Inbred C57BL Rabies Vaccines Receptors, IgG Vaccines, Synthetic Virion Virulence |
Data: | Out-2018 |
Editora: | Nature Research |
Revista: | Nature Communications |
Citação: | Abreu-Mota, T., Hagen, K. R., Cooper, K., Jahrling, P. B., Tan, G., Wirblich, C., ... & Schnell, M. J. (2018). Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever. Nature communications, 9(1), 4223 |
Resumo(s): | Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and, together with rabies, a major health burden in West Africa. Here we present the development and characterization of an inactivated recombinant LASV and rabies vaccine candidate (LASSARAB) that expresses a codon-optimized LASV glycoprotein (coGPC) and is adjuvanted by a TLR-4 agonist (GLA-SE). LASSARAB elicits lasting humoral response against LASV and RABV in both mouse and guinea pig models, and it protects both guinea pigs and mice against LF. We also demonstrate a previously unexplored role for non-neutralizing LASV GPC-specific antibodies as a major mechanism of protection by LASSARAB against LF through antibody-dependent cellular functions. Overall, these findings demonstrate an effective inactivated LF vaccine and elucidate a novel humoral correlate of protection for LF. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58718 |
DOI: | 10.1038/s41467-018-06741-w |
ISSN: | 2041-1723 |
e-ISSN: | 2041-1723 |
Versão da editora: | https://www.nature.com/articles/s41467-018-06741-w?campaign_url=https%3A%2F%2Fhospitals.jefferson.edu%2Fnews%2F2018%2F10%2FLassa-fever-virus-vaccine-and-new-test-for-immunity.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever.pdf | 1,57 MB | Adobe PDF | Ver/Abrir |