Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58478
Título: | The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions |
Autor(es): | Reis-Filho, Jorge S. Lakhani, Sunil R. |
Palavras-chave: | Breast Breast Neoplasms Carcinoma in Situ Carcinoma, Intraductal, Noninfiltrating Chromosome Aberrations Female Humans Hyperplasia Loss of Heterozygosity Neoplasm Invasiveness atypical ductal hyperplasia comparative genomic hybridisation ductal carcinoma in situ lobular carcinoma in situ |
Data: | 2003 |
Editora: | BioMed Central (BMC) |
Revista: | Breast Cancer Research |
Resumo(s): | The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58478 |
DOI: | 10.1186/bcr650 |
ISSN: | 1465-5411 |
e-ISSN: | 1465-542X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
bcr650.pdf | 144,76 kB | Adobe PDF | Ver/Abrir |