Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/57921
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira, Ana Isabel Ferreira | por |
dc.contributor.author | Magalhães, Ana Xavier Silva | por |
dc.contributor.author | Barbosa, Catarina Moreira | por |
dc.contributor.author | Magalhães, Hugo | por |
dc.contributor.author | Henrique, Rui | por |
dc.contributor.author | Jerónimo, Carmen | por |
dc.contributor.author | Costa, Bruno Marques | por |
dc.date.accessioned | 2019-01-08T14:57:29Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1752-0363 | - |
dc.identifier.uri | https://hdl.handle.net/1822/57921 | - |
dc.description.abstract | Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. Patients & methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Results: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility. However, the CC genotype in rs12826786 was significantly associated with shorter biochemical recurrence-free survival in pT3-stage PCa patients. Conclusion: Our results indicate that HOTAIR rs12826786 CC genotype may be an independent prognostic biomarker in a particular subset of PCa tumors. | por |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (IF/00601/2012 to BM Costa; SFRH/BD/52287/2013 to AI Oliveira; SFRH/BD/88220/2012 to AX Magalhaes), Fundação Calouste Gulbenkian (BM Costa), Liga Portuguesa Contra o Cancro (BM Costa) and Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC; to AI Oliveira and AX Magalhaes). Project co-financed by Programa Operacional Regional do Norte (ON.2-O Novo Norte), Quadro de Referencia Estratégico Nacional (QREN), Fundo Europeu de Desenvolvimento Regional (FEDER) and a grant (74-CI-IPOP) from Research Center of Portuguese Oncology Institute of Porto (C Jeronimo). | por |
dc.language.iso | eng | por |
dc.publisher | Future Medicine | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88220%2F2012/PT | por |
dc.rights | openAccess | - |
dc.subject | HOTAIR | por |
dc.subject | PCa | por |
dc.subject | rs12826786 | por |
dc.subject | rs920778 | por |
dc.subject | SNPs | por |
dc.title | Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.comments | author can archive post-print (ie final draft post-refereeing) | por |
oaire.citationStartPage | 257 | por |
oaire.citationEndPage | 264 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 12 | por |
dc.identifier.eissn | 1752-0371 | - |
dc.identifier.doi | 10.2217/bmm-2017-0258 | por |
dc.identifier.pmid | 29436234 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomarkers in Medicine | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Oliveira AI. Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival.pdf | 577,79 kB | Adobe PDF | Ver/Abrir |