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https://hdl.handle.net/1822/57880
Título: | A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics |
Autor(es): | Meira, Torcato Duarte Novo Leroy, Felix Buss, Eric W. Oliva, Azahara Park, Jung Siegelbaum, Steven A. |
Palavras-chave: | Animals CA1 Region, Hippocampal CA2 Region, Hippocampal Gene Silencing Male Mice, Inbred BALB C Mice, Inbred C57BL Nerve Net Nucleus Accumbens Pyramidal Cells Memory Social Behavior |
Data: | 2018 |
Editora: | Nature Publishing Group |
Revista: | Nature Communications |
Citação: | Meira, T., Leroy, F., Buss, E. W., Oliva, A., Park, J., & Siegelbaum, S. A. (2018, October 9). A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nature Communications. Springer Science and Business Media LLC. http://doi.org/10.1038/s41467-018-06501-w |
Resumo(s): | Recent results suggest that social memory requires the dorsal hippocampal CA2 region as well as a subset of ventral CA1 neurons. However, it is unclear whether dorsal CA2 and ventral CA1 represent parallel or sequential circuits. Moreover, because evidence implicating CA2 in social memory comes largely from long-term inactivation experiments, the dynamic role of CA2 in social memory remains unclear. Here, we use pharmacogenetics and optogenetics in mice to acutely and reversibly silence dorsal CA2 and its projections to ventral hippocampus. We show that dorsal CA2 activity is critical for encoding, consolidation, and recall phases of social memory. Moreover, dorsal CA2 contributes to social memory by providing strong excitatory input to the same subregion of ventral CA1 that contains the subset of neurons implicated in social memory. Thus, our studies provide new insights into a dorsal CA2 to ventral CA1 circuit whose dynamic activity is necessary for social memory. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57880 |
DOI: | 10.1038/s41467-018-06501-w |
ISSN: | 2041-1723 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Meira T. A hippocampal circuit.pdf | 4,74 MB | Adobe PDF | Ver/Abrir |