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https://hdl.handle.net/1822/57829
Título: | Metabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress |
Autor(es): | Ferreira, Ana Catarina Sousa, Nuno Peixoto, João Miguel Seiça Bessa Sousa, João Carlos Marques, Fernanda |
Palavras-chave: | Neurogenesis Metabolism Oxidative stress Lipocalin-2 |
Data: | Dez-2018 |
Editora: | Pergamon-Elsevier Science Ltd |
Revista: | Neuroscience and Biobehavioral Reviews |
Citação: | Ferreira, A. C., Sousa, N., Bessa, J. M., Sousa, J. C., & Marques, F. (2018). Metabolism and adult neurogenesis: towards an understanding of the role of lipocalin-2 and iron-related oxidative stress. Neuroscience & Biobehavioral Reviews |
Resumo(s): | The process of generating new functional neurons in the adult mammalian brain occurs from the local neural stem and progenitor cells and requires tight control of the progenitor cell's activity. Several signaling pathways and intrinsic/extrinsic factors have been well studied over the last years, but recent attention has been given to the critical role of cellular metabolism in determining the functional properties of progenitor cells. Here, we review recent advances in the current understanding of when and how metabolism affects neural stem cell (NSC) behavior and subsequent neuronal differentiation and highlight the role of lipocalin-2 (LCN2), a protein involved in the control of oxidative stress, as a recently emerged regulator of NSC activity and neuronal differentiation. |
Tipo: | Artigo |
Descrição: | Accepted manuscript |
URI: | https://hdl.handle.net/1822/57829 |
DOI: | 10.1016/j.neubiorev.2018.09.014 |
ISSN: | 0149-7634 |
e-ISSN: | 1873-7528 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S014976341830280X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Ferreira AC. Metabolism and adult neurogenesis towards an understanding of the role of lipocalin 2 and iron related oxidative stress.pdf | 960,04 kB | Adobe PDF | Ver/Abrir |