Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/56277
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Harada, L. K. | por |
dc.contributor.author | Pereira, J. F. B. | por |
dc.contributor.author | Campos, W. F. | por |
dc.contributor.author | Silva, E. C. | por |
dc.contributor.author | Moutinho, Carla G. | por |
dc.contributor.author | Vila, Marta M. D. C. | por |
dc.contributor.author | Oliveira Jr., J. M. | por |
dc.contributor.author | Teixeira, J. A. | por |
dc.contributor.author | Balcão, Victor M. | por |
dc.contributor.author | Tubino, M. | por |
dc.date.accessioned | 2018-10-17T16:19:28Z | - |
dc.date.available | 2018-10-17T16:19:28Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Harada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 2018 | por |
dc.identifier.issn | 0103-5053 | por |
dc.identifier.uri | https://hdl.handle.net/1822/56277 | - |
dc.description.abstract | Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper. | por |
dc.description.sponsorship | Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) (FAPESP Refs. No. 2016/08884-3 (Project PneumoPhageColor) and 2016/12234-4 (Project TransAppIL)) is hereby gratefully acknowledged. Funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Ref. No. 2016/16641-3) in the form of an MSc fellowship granted to Liliam Harada is hereby gratefully acknowledged. This work also received support from CNPq, National Council for Scientific and Technological Development, Brazil, in the form of Research Productivity (PQ) fellowships granted to Victor M. Balcão (Refs. No. 306113/2014-7 and 308208/2017-0). | por |
dc.language.iso | eng | por |
dc.publisher | Sociedade Brasileira de Química | por |
dc.rights | openAccess | por |
dc.subject | ionic liquids | por |
dc.subject | structural and functional stabilization | por |
dc.subject | protein stability | por |
dc.subject | biopharmaceutical applications | por |
dc.subject | transdermal drug delivery | por |
dc.subject | Functional stabilization | por |
dc.subject | Structural | por |
dc.title | Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://jbcs.sbq.org.br | por |
dc.comments | CEB48977 | por |
oaire.citationStartPage | 1983 | por |
oaire.citationEndPage | 1998 | por |
oaire.citationIssue | 10 | por |
oaire.citationConferencePlace | Brazil | - |
oaire.citationVolume | 29 | por |
dc.date.updated | 2018-10-17T15:33:48Z | - |
dc.identifier.doi | 10.21577/0103-5053.20180141 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of the Brazilian Chemical Society | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_48977_1.pdf | 2 MB | Adobe PDF | Ver/Abrir |