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https://hdl.handle.net/1822/51280
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Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira, Ana I. | por |
dc.contributor.author | Pinho, Claudia | por |
dc.contributor.author | Sarmento, Bruno | por |
dc.contributor.author | Dias, Alberto Carlos Pires | por |
dc.date.accessioned | 2018-02-28T22:01:25Z | - |
dc.date.available | 2018-02-28T22:01:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1664-462X | por |
dc.identifier.uri | https://hdl.handle.net/1822/51280 | - |
dc.description.abstract | Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as St. Johns wort. It has been used for centuries in traditional medicine for the treatment of several disorders, such as minor burns, anxiety, and mild to moderate depression. In the past years, its antidepressant properties have been extensively studied. Despite that, other H. perforatum biological activities, as its neuroprotective properties have also been evaluated. The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. As for this, it has been demonstrated that H. perforatum extracts and several of its major molecular components have the ability to protect against toxic insults, either directly, through neuroprotective mechanisms, or indirectly, through is antioxidant properties. H. perforatum has therefore the potential to become an effective neuroprotective therapeutic agent, despite further studies that need to be carried out. | por |
dc.description.sponsorship | This work was supported by Fundacao para a Ciencia e Tecnologia (FCT), projects PTDC/AGR-ALI/105169/2008, PEst-OE/AGR/UI4033/2014. AO was supported by Escola Superior de Tecnologia da Saude do Porto and Instituto Politecnico do Porto (Programa de Formacao Avancada de Docentes). | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105169/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/135895/PT | por |
dc.rights | openAccess | por |
dc.subject | Hypericum perforatum | por |
dc.subject | extracts | por |
dc.subject | compounds | por |
dc.subject | neuroprotection | por |
dc.subject | antioxidant activity | por |
dc.title | Neuroprotective activity of Hypericum perforatum and its major components | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
oaire.citationIssue | JULY 2016 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2018-02-28T21:52:32Z | - |
dc.identifier.doi | 10.3389/fpls.2016.01004 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 2803 | - |
sdum.journal | Frontiers in Plant Science | por |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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(2016)-FRONTIERS_NEUROPROTECCAO.pdf | 652,6 kB | Adobe PDF | Ver/Abrir |