Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells

doi:10.1016/j.ejmech.2017.11.059

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/50165

Título:	Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Autor(es):	Teixeira, Ricardo G. Brás, Ana Rita Côrte-Real, Leonor Tatikonda, Rajendhraprasad Sanches, Anabela Robalo, M. Paula Avecilla, Fernando Moreira, Tiago Manuel Martins Garcia, M. Helena Haukka, Matti Preto, Ana Valente, Andreia
Palavras-chave:	Apoptosis Colorectal cancer Ruthenium methylcyclopentadienyl Selectivity
Data:	1-Jan-2018
Editora:	Elsevier 1
Revista:	European Journal of Medicinal Chemistry
Resumo(s):	Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
Tipo:	Artigo
URI:	https://hdl.handle.net/1822/50165
DOI:	10.1016/j.ejmech.2017.11.059
ISSN:	0223-5234
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	DBio - Artigos/Papers