Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49932
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Pinheiro, Céline | por |
dc.contributor.author | Granja, Sara Costa | por |
dc.contributor.author | Longatto, Adhemar | por |
dc.contributor.author | Faria, André M. | por |
dc.contributor.author | Fragoso, Maria C. B. V. | por |
dc.contributor.author | Lovisolo, Silvana M. | por |
dc.contributor.author | Bonatelli, Murilo | por |
dc.contributor.author | Costa, Ricardo F.A. | por |
dc.contributor.author | Lerário, Antonio M. | por |
dc.contributor.author | Almeida, Madson Q. | por |
dc.contributor.author | Baltazar, Fátima | por |
dc.contributor.author | Zerbini, Maria C.N. | por |
dc.date.accessioned | 2018-01-31T10:34:58Z | - |
dc.date.available | 2018-01-31T10:34:58Z | - |
dc.date.issued | 2017-09-03 | - |
dc.identifier.citation | Pinheiro, C., Granja, S., Longatto-Filho, A., Faria, A. M., Fragoso, M. C., Lovisolo, S. M., ... & Baltazar, F. (2017). GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior. Oncotarget, 8(38), 63835 | por |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://hdl.handle.net/1822/49932 | - |
dc.description.abstract | Background: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors. Methods: A total of 50 pediatric patients presenting adrenocortical tumors, including 41 clinically benign and 9 clinically malignant tumors, were included. Protein expression was evaluated using immunohistochemistry in samples arranged in tissue microarrays. Results: The immunohistochemical analysis showed a significant increase in plasma membrane expression of GLUT1 in malignant lesions, when compared to benign lesions (p=0.004), being the expression of this protein associated with shorter overall and disease-free survival (p=0.004 and p=0.001, respectively). Although significant differences were not observed for proteins other than GLUT1, MCT1, MCT4 and CD147 were highly expressed in pediatric adrenocortical neoplasias (around 90%). Conclusion: GLUT1 expression was differentially expressed in pediatric adrenocortical tumors, with higher expression in clinically malignant tumors, and associated with shorter survival, suggesting a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy. | por |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) to Maria Claudia Nogueira Zerbini (2013/26344-8) and under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and by FEDER, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038 | por |
dc.language.iso | eng | por |
dc.publisher | Impact Journals | por |
dc.rights | openAccess | por |
dc.subject | Pediatric adrenocortical tumors | por |
dc.subject | Metabolic reprogramming | por |
dc.subject | Monocarboxylate transporter | por |
dc.subject | Glucose transporter | por |
dc.subject | Warburg effect | por |
dc.title | GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19135&path[]=61295 | por |
oaire.citationStartPage | 63835 | por |
oaire.citationEndPage | 63845 | por |
oaire.citationIssue | 38 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2018-01-09T16:11:23Z | - |
dc.identifier.doi | 10.18632/oncotarget.19135 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Oncotarget | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |