Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49596
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Esteves, Madalena Curva | por |
dc.contributor.author | Marques, P. | por |
dc.contributor.author | Magalhães, Ricardo José Silva | por |
dc.contributor.author | Castanho, Teresa Jesus Costa | por |
dc.contributor.author | Soares, José Miguel Montenegro | por |
dc.contributor.author | Almeida, Armando | por |
dc.contributor.author | Santos, Nadine Correia | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Leite-Almeida, Hugo | por |
dc.date.accessioned | 2018-01-24T10:48:01Z | - |
dc.date.available | 2018-01-24T10:48:01Z | - |
dc.date.issued | 2017-06-20 | - |
dc.identifier.citation | Esteves, M., Marques, P., Magalhães, R., Castanho, T. C., Soares, J. M., Almeida, A., ... & Leite-Almeida, H. (2017). Structural laterality is associated with cognitive and mood outcomes: An assessment of 105 healthy aged volunteers. NeuroImage, 153, 86-96 | por |
dc.identifier.issn | 1662-5153 | - |
dc.identifier.uri | https://hdl.handle.net/1822/49596 | - |
dc.description.abstract | The human brain presents multiple asymmetries that dynamically change throughout life. These phenomena have been associated with cognitive impairments and psychiatric disorders although possible associations with specific patterns of cognitive aging are yet to be determined. We have therefore mapped and quantified morphological asymmetries in a heterogeneous and aged population (65.2 +/- 8.0 years old, 52 male and 53 female) to explore potential associations between the asymmetries in specific brain regions and cognitive performance. The sample was characterized in a battery of neuropsychological tests and in terms of brain structural asymmetries using a ROI-based approach. A substantial number of brain areas presented some degree of asymmetry. Such biases survived a stringent statistical correction and were largely confirmed in a voxel-based analysis. In specific brain areas, like the thalamus and insula, asymmetry was correlated with cognition and mood descriptors as the Stroop words/colors test or depressive mood scale, respectively. Curiously in the latter, the association was independent of its left/right direction. Altogether, results reveal that asymmetry is widespread in the aged brain and that area-specific biases (degree and direction) associate with the functional profile of the individual. | por |
dc.description.sponsorship | European Commission (FP7): “SwitchBox” [contract HEALTH-F2-2010-259772] and Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER) – PM and NCS; Fundação para a Ciência e a Tecnologia (FCT) [grant numbers SFRH/BD/52291/2013 to ME via Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC), SFRH/BPD/80118/2011 to HA and SFRH/BD/90078/2012 to TCC]; and FCT/MEC and ON.2 – ONOVONORTE – North Portugal Regional Operational Programme 2007/2013, of the National Strategic Reference Framework (NSRF) 2007/2013, through FEDER [project FCTANR/NEU-OSD/0258/2012 to RM] | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Aging | por |
dc.subject | Cognition | por |
dc.subject | Mood | por |
dc.subject | Laterality | por |
dc.subject | MRI | por |
dc.title | Structural laterality is associated with cognitive and mood outcomes: An assessment of 105 healthy aged volunteers | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1053811917302483 | por |
oaire.citationStartPage | 86 | por |
oaire.citationEndPage | 96 | por |
oaire.citationVolume | 153 | por |
dc.date.updated | 2018-01-08T10:56:00Z | - |
dc.identifier.doi | 10.1016/j.neuroimage.2017.03.040 | por |
dc.identifier.pmid | 28341162 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neuroimage | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2017 - neuroimage.pdf | 1,38 MB | Adobe PDF | Ver/Abrir |