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https://hdl.handle.net/1822/49577
Título: | The choroid plexus as a sex hormone target: Functional implications |
Autor(es): | Santos, Cecília R.A. Duarte, Ana Catarina Quintela, Telma Tomás, Joana Albuquerque, Tânia Marques, Fernanda Palha, Joana Almeida Gonçalves, Isabel |
Palavras-chave: | Choroid plexus Brain barriers Immune surveillance Cerebrospinal fluid Chemical surveillance Sex hormones Circadian rhythm Olfactory signalling Neurogenesis Taste signalling |
Data: | 8-Jan-2017 |
Editora: | Elsevier 1 |
Revista: | Frontiers in Neuroendocrinology |
Citação: | Santos, C. R., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., ... & Gonçalves, I. (2016). The choroid plexus as a sex hormone target: Functional implications. Frontiers in neuroendocrinology |
Resumo(s): | The choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation. Sex hormones (SH) are widely recognized as modulators in several neurodegenerative diseases, and there is evidence that estrogens and androgens regulate several fundamental biological functions in the CPs. Therefore, SH are likely to affect the composition of the CSF impacting on brain homeostasis. This review will look at implications of the CPs' sex-related specificities. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/49577 |
DOI: | 10.1016/j.yfrne.2016.12.002 |
ISSN: | 0091-3022 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0091302216300620 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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santos_2017.pdf | 1,68 MB | Adobe PDF | Ver/Abrir |