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https://hdl.handle.net/1822/49111| Título: | The relation of HPV infection and expression of p53 and p16 proteins in esophageal squamous cells carcinoma |
| Autor(es): | Pastrez, Paula Roberta Aguiar Mariano, Vânia Sammartino Costa, Allini Mafra da Silva, Estela Maria Scapulatempo-Neto, Cristovam Guimarães, Denise Peixoto Fava, Gilberto Neto, Said Abdala Zemi Nunes, Emily Montosa Longatto Filho, Adhemar et. al. |
| Palavras-chave: | Esophageal neoplasias p16 p53 Immunohistochemistry HPV |
| Data: | 25-Abr-2017 |
| Editora: | Ivyspring International Publisher |
| Revista: | Journal of Cancer |
| Citação: | Pastrez, P. R. A., Mariano, V. S., da Costa, A. M., Silva, E. M., Scapulatempo-Neto, C., Guimarães, D. P., ... & Villa, L. L. (2017). The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma. Journal of Cancer, 8(6), 1062 |
| Resumo(s): | GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) was found in the same frequency (13.8%) in esophageal squamous cell carcinoma (ESCC) and in healthy individuals. The p53 expression was positive in 67.5% of tumor tissue, 20.0% of adjacent non-tumoral tissue and 1.8% of normal esophageal tissue. p16 was positive in 11.6% of esophageal cancer cases and 4.7% of adjacent non-tumoral tissue. p16 was undetectable among control group samples. p53 and p16 levels were not significantly associated with the HPV status. CONCLUSIONS: These results suggest that hr-HPV types are not associated with the development of ESCC and that p53 and p16 protein expression have no relationship with HPV infection in normal or cancerous esophagus. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/49111 |
| DOI: | 10.7150/jca.17080 |
| ISSN: | 1837-9664 |
| Versão da editora: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436260/ |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
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