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https://hdl.handle.net/1822/48394
Título: | The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A |
Autor(es): | Samanfar, Bahram Shostak, Kristina Moteshareie, Houman Hajikarimlou, Maryam Shaikho, Sarah Omidi, Katayoun Hooshyar, Mohsen Burnside, Daniel Galván Márquez, Imelda Ludovico, Paula |
Palavras-chave: | Yeast Gene deletion HSP Protein expression Saccharomyces cerevisiae Acetic acid Heat shock DOM34 and RPL36A DOM34 RPL36A |
Data: | 14-Nov-2017 |
Editora: | Peerj, Inc. |
Revista: | PeerJ |
Resumo(s): | The presence of acetic acid during industrial alcohol fermentation reduces the yield of fermentation by imposing additional stress on the yeast cells. The biology of cellular responses to stress has been a subject of vigorous investigations. Although much has been learned, details of some of these responses remain poorly understood. Members of heat shock chaperone HSP proteins have been linked to acetic acid and heat shock stress responses in yeast. Both acetic acid and heat shock have been identified to trigger different cellular responses including reduction of global protein synthesis and induction of programmed cell death. Yeast HSC82 and HSP82 code for two important heat shock proteins that together account for 1-2% of total cellular proteins. Both proteins have been linked to responses to acetic acid and heat shock. In contrast to the overall rate of protein synthesis which is reduced, the expression of HSC82 and HSP82 is induced in response to acetic acid stress. In the current study we identified two yeast genes DOM34 and RPL36A that are linked to acetic acid and heat shock sensitivity. We investigated the influence of these genes on the expression of HSP proteins. Our observations suggest that Dom34 and RPL36A influence translation in a CAP-independent manner. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/48394 |
DOI: | 10.7717/peerj.4037 |
ISSN: | 2167-8359 |
e-ISSN: | 2167-8359 |
Versão da editora: | https://peerj.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |