Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46255
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Campo DC | Valor | Idioma |
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dc.contributor.author | Sheeba, Caroline Jeya | por |
dc.contributor.author | Andrade, Raquel P. | por |
dc.contributor.author | Esteves, Isabel Maria Mestre Marques Palmeirim Alfarra | por |
dc.date.accessioned | 2017-07-24T13:11:27Z | - |
dc.date.available | 2017-07-24T13:11:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1084-9521 | por |
dc.identifier.uri | https://hdl.handle.net/1822/46255 | - |
dc.description.abstract | Development of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are differentially sculptured along the proximal-distal, anterior-posterior and dorsal-ventral axes to form a functional limb. Complementary experimental approaches in different organisms have enhanced our knowledge on the molecular events underlying limb development. Herein, we summarize the current knowledge of the main signaling mechanisms governing vertebrate limb initiation, outgrowth, specification of limb segments and termination. | por |
dc.description.sponsorship | C.J.S. was supported by Fundação para a Ciência e a Tecnologia, Portugal (grant SFRH/BPD/89493/2012); R.P.A. is funded by Programa Operacional Regional do Norte (ON.2) NORTE-07-0124-FEDER-000017. This work was supported by research grants from Institute for Biotechnology and Bioengineering/Centro de Biomedicina Molecular e Estrutural, LA (to I.P.), by Fundação para a Ciência e a Tecnologia (National and FEDER COMPETE Program funds: PTDC/BIM-MED/1063/2012 and PTDC/SAU-BID/121459/2010 to I.P. and R.P.A., respectively) and by PEst-OE/EQB/LA0023/2011. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F89493%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/125901/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121459/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/121459/PT | - |
dc.relation | PEst-OE/EQB/LA0023/2011 | - |
dc.rights | openAccess | por |
dc.subject | Limb development | por |
dc.subject | Patterning | por |
dc.subject | Limb molecular clock | por |
dc.subject | Molecular interactions | por |
dc.subject | Signaling gradients | por |
dc.title | Getting a handle on embryo limb development: molecular interactions driving limb outgrowth and patterning | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1084952115000099 | por |
oaire.citationStartPage | 92 | por |
oaire.citationEndPage | 101 | por |
oaire.citationTitle | Seminars in Cell and Developmental Biology | por |
oaire.citationVolume | 49 | por |
dc.date.updated | 2017-07-20T13:37:15Z | - |
dc.identifier.doi | 10.1016/j.semcdb.2015.01.007 | por |
dc.identifier.pmid | 25617599 | por |
dc.description.publicationversion | info:eu-repo/semantics/acceptedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Seminars in Cell and Developmental Biology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-s1084952115000099-main.pdf | 2,16 MB | Adobe PDF | Ver/Abrir |