Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46166
Título: | Genetically engineered Silk-Elastin-Like Proteins as a versatile platform for the development of new biomaterials |
Autor(es): | Machado, Raul Costa, André Manuel Abreu Pereira, Ana Margarida Macedo Bernardes Silva, Andreia Maria Gomes, Diana Gomes, Andreia C Lanceros-Méndez, S. Sencadas, Vítor João Gomes Silva Rodriguez-Cabello, José Carlos Casal, Margarida |
Data: | Jun-2017 |
Resumo(s): | [Excerpt] Throughout evolution nature created and refined proteins for a wide range of functions, working as structural components or as molecular motors. In this sense, the natural fibrous proteins represent the utmost case of function specialization and high performance materials. The remarkable mechanical properties of proteins like elastin or silk are founded on conservative blocks of amino acid sequences that propagate through the natural protein. These repetitive amino acid sequences are arranged in a way that creates flexible, rigid or tough domains, which are responsible for the physical and mechanical properties of the natural protein. Indeed, the recognition of the mechanics linking the nano- and micro-scale structure with the macromolecular assembly and organization, enabled molecular biologists to understand nature’s refined ways of creating high performance structural materials. Advances in synthetic protein biotechnology, emerging from the increase of knowledge in structural and molecular biology, combined with the use of recombinant DNA technology and biotechnology processes, made possible the advent of a new class of artificial biomacromolecules, the recombinant Protein-Based Polymers (rPBPs). This new class of protein-based materials, inspired in nature and with precisely controlled amino acid sequences, mimic the properties of their natural counterparts but can also combine in the same polypeptide chain the properties of two or more different proteins, creating copolymers with distinct properties from their native equivalents. Indeed, by recombinant DNA technology, it is possible to design and produce tailored synthetic genes, allowing for the creation of multifunctional complex PBPs with absolute control of its composition, structure and molecular weight. [...] |
Tipo: | Comunicação oral |
URI: | https://hdl.handle.net/1822/46166 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CBMA - Comunicações/Communications in Congresses CDF - FCD - Comunicações/Communications (with refereeing) DBio - Comunicações/Communications in Congresses |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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RMachado_JPG2017.pdf | 313,35 kB | Adobe PDF | Ver/Abrir |