Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/45084
Título: | Selection of a molecule that specifically targets the cell-surface Human Epidermal growth factor Receptor 2: in silico docking simulation |
Autor(es): | Sousa, Diana Andrade Ferreira, Débora Silva, A. Kluskens, Leon Rodrigues, L. R. |
Data: | 23-Fev-2017 |
Citação: | Sousa, Diana; Ferreira, Débora; Silva, A.; Kluskens, Leon D.; Rodrigues, Lígia R., Selection of a molecule that specifically targets the cell-surface Human Epidermal growth factor Receptor 2: in silico docking simulation. BOD 2017 - Bioinformatics Open Days (Book Conference). Braga, Feb 23-24, 2017. |
Resumo(s): | [Excerpt] Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths.1 Human Epidermal growth factor Receptor 2 (HER2) is a protein that is overexpressed in 25-30% of breast cancers and is involved in cell growth regulation, survival and differentiation.2 Aptamers generated from Systematic Evolution of Ligands by EXponential Enrichment (SELEX) emerged as a potential new tool for the development of targeted cancer therapies due to their three-dimensional structures that specifically recognize cell surface receptors, such as HER2.3 In this study, HER2-aptamers were screened and identified using SELEX. To design an approach for computational analysis of the isolated aptamers, their structures were modelled by mfold4, a web-based methodology for DNA structure prediction and hybridization software. The HER2 protein structure was obtained from Protein Data Bank (PDB) and using ZDOCK server5, the aptamer-target interactions were predicted through a combination of shape complementarity and statistical potential terms for scoring. [...] |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/45084 |
Versão da editora: | http://www.bioinformaticsopendays.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_46707_1.pdf | 118,78 kB | Adobe PDF | Ver/Abrir |