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https://hdl.handle.net/1822/45056
Título: | Biological importance of structurally diversified chromenes |
Autor(es): | Costa, M. Dias, T. A. Brito, A. Proença, F. |
Palavras-chave: | Chromene Natural products Synthetic analogues Biological activity |
Data: | Nov-2016 |
Editora: | Elsevier 1 |
Revista: | European Journal of Medicinal Chemistry |
Citação: | Costa, M., Dias, T. A., Brito, A., & Proença, F. (2016). Biological importance of structurally diversified chromenes. [Review]. European Journal of Medicinal Chemistry, 123, 487-507. doi: 10.1016/j.ejmech.2016.07.057 |
Resumo(s): | Compounds incorporating the chromene scaffold are largely present in natural products and display a wide variety of biological activities. Their low toxicity combined to the broad pharmacological properties have inspired medicinal chemists in the search for new therapeutic agents. This review covers the literature between 1993 and on the biological activity of 2H- and 4H-chromenes, both from natural and synthetic origin. Includes a section that identifies a selection of chromene-based natural products, followed by recent literature on bioactive natural chromenes and the corresponding source, covering plants and fruits. Synthetic chromenes are equally important and a separate section addresses the use of these derivatives as new leads for drug discovery. Different biological targets were identified, namely those associated with anticancer, antimicrobial, anti-inflammatory, antithrombotic and antipsychotic activities. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/45056 |
DOI: | 10.1016/j.ejmech.2016.07.057 |
ISSN: | 0223-5234 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0223523416306201 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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costa2016.pdf Acesso restrito! | 4,99 MB | Adobe PDF | Ver/Abrir |