Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/45054
Título: | Mucosal healing in ulcerative colitis – when zero is better |
Autor(es): | Carvalho, Pedro Boal Castro, Francisca Dias de Rosa, Bruno Moreira, Maria João Cotter, José de Almeida Berkeley |
Palavras-chave: | Ulcerative colitis Mucosal healing Mayo score Inflammatory bowel diseases |
Data: | 2016 |
Editora: | Oxford University Press |
Revista: | Journal of Crohn's and Colitis |
Citação: | Carvalho, P. B., De Castro, F. D., Rosa, B., Moreira, M. J., & Cotter, J. (2016). Mucosal healing in ulcerative colitis - when zero is better. [Article]. Journal of Crohn's and Colitis, 10(1), 20-25. doi: 10.1093/ecco-jcc/jjv180 |
Resumo(s): | Background and aims: Extensive evidence has underlined the importance of mucosal healing as a treatment aim for ulcerative colitis (UC). We aimed to assess differences in the incidence of clinical relapse at 12 months between UC patients with Mayo endoscopic scores (MES) 0 and 1. Methods: This retrospective study included consecutive patients in corticosteroid-free remission between 2008 and 2013 and with follow-up of at least 1 year, with MES 0 or 1 in complete colonoscopy. Clinical relapse was defined as need for induction treatment, treatment escalation, hospitalization or surgery. A p value < 0.05 was considered statistically significant. Results: The study included 138 patients, 72 (52.2%) female, with mean age of 49 (+/- 14) years. Inflammatory activity was classified as MES 0 in 61 (44.2%) patients and MES 1 in 77 (55.8%) patients. Clinical relapse during follow-up was significantly more frequent in patients with MES 1 than MES 0 (27.3 vs 11.5%, p = 0.022), and in the multivariate analysis MES 1 was the only factor significantly associated with an increased risk of relapse (odds ratio 2.89, 95% confidence interval 1.14-7.36, p = 0.026). This association was encountered in the subgroup of patients with left-sided/ extensive colitis (29.7 vs 11.1%, p = 0.049), but not proctitis (25.0 vs 12.0%, p = 0.202). Conclusions: In patients with UC in corticosteroid-free remission, particularly those with left-sided colitis or extensive colitis, MES 1 was significantly associated with a 3-fold increased risk of relapse compared with endoscopic MES 0. Our results support the use of endoscopic MES 0 as the most suitable treatment endpoint to define mucosal healing in patients with UC. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/45054 |
DOI: | 10.1093/ecco-jcc/jjv180 |
ISSN: | 1873-9946 |
e-ISSN: | 1876-4479 |
Versão da editora: | https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjv180 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
mucosal healing in ulcerative colitis.pdf | 730,7 kB | Adobe PDF | Ver/Abrir |