Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44848
Título: | Randomised short-term trial of high-span versus low-span APAP for treating sleep apnoea |
Autor(es): | Bastos, Hélder Novais Cardoso, Ana Verónica Castro, Ana Sofia Gomes, Rita Pinto, Tiago Marinho, Anabela Sucena, Maria Almeida, João Drummond, Marta Winck, João Carlos |
Palavras-chave: | Obstructive sleep apnoea Auto-titrating positive airway pressure Pressure range Treatment compliance |
Data: | Mar-2016 |
Editora: | Springer Verlag |
Revista: | Sleep and Breathing |
Citação: | Bastos, H. N., Cardoso, A. V., Castro, A. S., Gomes, R., Pinto, T., et. al (2016). Randomised short-term trial of high-span versus low-span APAP for treating sleep apnoea. Sleep and Breathing, 20(1), 183-190 |
Resumo(s): | PURPOSE: Auto-titrating continuous positive airway pressure (APAP) devices were developed to improve treatment efficacy and compliance in patients with obstructive sleep apnoea syndrome (OSAS). Since there are insufficient data on the optimal pressure range setting, we aimed to compare the adherence, efficacy and tolerability of treatment with high-span versus low-span APAP. METHODS: Seventy-six newly diagnosed OSAS patients fulfilling the treatment criteria were randomised to receive high-span (HS, range 4-15cmH2O, n?=?38) or low-span (LS, range 8-12cmH2O, n?=?38) APAP. Patients were assessed at 1 and 3 months. RESULTS: Median Epworth sleepiness scale (ESS) was 13 (IQR, 6-16) and median apnoea-hypopnoea index (AHI) was 35.9 (IQR, 27.6-56.3). There were no significant differences in baseline demographic and clinical characteristics between groups. Overall, no significant differences were found at the first month assessment. After 3 months of therapy, we found again no differences in residual AHI or ESS. However, the group HS proved less adherent than group LS, respectively, with median 87 % (IQR, 60.5-97.5) versus 94 % (IQR, 80.0-98.3) of the nights using =4 h (P?=?0.014) and mean (±SD) usage 5.7?±?1.6 versus 6.4?±?1.2 h/night (P?=?0.049). The group HS reported more frequently nasal congestion, excessive oronasal dryness and nocturnal awakenings of at least moderate intensity, the latter with statistical significance (P?=?0.005). CONCLUSIONS: Both pressure ranges appear to be equally effective to correct AHI and to improve symptoms. Though, patients with high-span APAP were less compliant to treatment, raising issues about the tolerability of wide pressure range settings of these devices. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44848 |
DOI: | 10.1007/s11325-015-1203-1 |
ISSN: | 1520-9512 |
Versão da editora: | http://link.springer.com/article/10.1007%2Fs11325-015-1203-1 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |