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https://hdl.handle.net/1822/44742
Título: | MAHMI database: a comprehensive MetaHit-based resource for the study of the mechanism of action of the human microbiota |
Autor(es): | Blanco-Míguez, Aitor Gutiérrez-Jácome, Alberto Fdez-Riverola, Florentino Lourenço, Anália Sánchez, Borja |
Data: | 2017 |
Editora: | Oxford University Press |
Revista: | Database - the Journal of Biological Databases and Curation |
Citação: | Blanco-Míguez, Aitor; Gutiérrez-Jácome, Alberto; Fdez-Riverola, Florentino; Lourenço, Anália; Sánchez, Borja, MAHMI database: a comprehensive MetaHit-based resource for the study of the mechanism of action of the human microbiota. Database - The Journal of Biological Databases and Curation, 2017(1), baw157, 2017 |
Resumo(s): | The Mechanism of Action of the Human Microbiome (MAHMI) database is a unique resource that provides comprehensive information about the sequence of potential immunomodulatory and antiproliferative peptides encrypted in the proteins produced by the human gut microbiota. Currently, MAHMI database contains over 300 hundred million peptide entries, with detailed information about peptide sequence, sources and potential bioactivity. The reference peptide data section is curated manually by domain experts. The in silico peptide data section is populated automatically through the systematic processing of publicly available exoproteomes of the human microbiome. Bioactivity prediction is based on the global alignment of the automatically processed peptides with experimentally validated immunomodulatory and antiproliferative peptides, in the reference section. MAHMI provides researchers with a comparative tool for inspecting the potential immunomodulatory or antiproliferative bioactivity of new amino acidic sequences and identifying promising peptides to be further investigated. Moreover, researchers are welcome to submit new experimental evidence on peptide bioactivity, namely, empiric and structural data, as a proactive, expert means to keep the database updated and improve the implemented bioactivity prediction method. Bioactive peptides identified by MAHMI have a huge biotechnological potential, including the manipulation of aberrant immune responses and the design of new functional ingredients/foods based on the genetic sequences of the human microbiome. Hopefully, the resources provided by MAHMI will be useful to those researching gastrointestinal disorders of autoimmune and inflammatory nature, such as Inflammatory Bowel Diseases. MAHMI database is routinely updated and is available free of charge. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44742 |
DOI: | 10.1093/database/baw157 |
ISSN: | 1758-0463 |
e-ISSN: | 1758-0463 |
Versão da editora: | http://database.oxfordjournals.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46644_1.pdf | 1,18 MB | Adobe PDF | Ver/Abrir |