Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/44326
Título: | Evaluation of canine adipose-derived stem cells in a healthy mice subcutaneous model |
Autor(es): | Requicha, J. F. Carvalho, P. P. Pires, M. A. Dias, M. I. Reis, R. L. Gomes, Manuela E. Viegas, C. A. A. |
Palavras-chave: | Canine adipose-derived stem cells Mice subcutaneous model Dog Xenotransplantation; Host response Mice model |
Data: | Dez-2016 |
Revista: | Journal of Stem Cell Research & Therapy |
Citação: | Requicha J. F., Carvalho P. P., Pires M. A., Dias M. I., Reis R. L., Gomes M. E., Viegas C. A. A. Evaluation of Canine Adipose-derived Stem Cells in a Healthy Mice Subcutaneous Model, Journal of Stem Cell Research & Therapy, Vol. 6, Issue 9, doi:10.4172/2157-7633.1000358, 2016 |
Resumo(s): | Canine adipose-derived stem cells (cASCs) have great interest for cell-based therapies in Veterinary Medicine. As the behaviour of these cells in non-autologous recipients is not deeply characterized, it is mandatory to study them in new animal models previously to canine specie. In this work, cASCs were injected subcutaneously in mice and these cells were detected by immunohistochemistry using vimentin, CD44 and keratin. The local response evaluated by histology did not reveal signals of significant inflammatory reaction neither in the lymph nodes or other organs. This study showed the implantation of cASCs induced a scarce inflammatory response. Hsd:CD1 (ICR) mouse can be proposed as an animal model to study the in vivo behavior of the cASCs and to validate new cASCs-based approaches avoiding or reducing the use of dogs in research. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/44326 |
DOI: | 10.4172/2157-7633.1000358 |
ISSN: | 2157-7633 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18968-JoãoRequicha_JSCRR2016.pdf | 525,92 kB | Adobe PDF | Ver/Abrir |