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https://hdl.handle.net/1822/42639
Título: | Inflammatory response study of gellan gum impregnated duck’s feet derived collagen sponges |
Autor(es): | Song, Jeong Eun Lee, Seon Eui Cha, Se Rom Janga, Na Keum Tripathy, Nirmalya Reis, R. L. Khang, Gilson |
Palavras-chave: | Collagen Gellan gum Inflammatory responses Sponge Tissue regeneration |
Data: | 2016 |
Editora: | Taylor and Francis |
Revista: | Journal of Biomaterials Science. Polymer Edition |
Citação: | Song J. E., Lee S. E., Cha S. R., Jang N. K., Tripathy N., Reis R. L., Khang G. Inflammatory Response Study of Gellan Gum Impregnated DucFeet Derived Collagen Sponges, Journal of Biomaterials Science, Polymer Edition, Vol. 27, Issue 15, pp. 1495–1506, doi:10.1080/09205063.2016.1213218, 2016 |
Resumo(s): | Tissue engineered biomaterials have biodegradable and biocompatible properties. In this study, we have fabricated sponges using duck's feet derived collagen (DC) and gellan gum (GG), and further studied its inflammatory responses. The as-prepared duck's feet DC/GG sponges showed the possibility of application as a tissue engineering material through in vitro and in vivo experiments. The physical and chemical properties of sponges were characterized by compression strength, porosity, and scanning electron microscopy, etc. In vitro cell viability were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. An inflammatory response was studied after seeding RAW264.7 cells on as-fabricated sponges using reverse transcriptase-polymerase chain reaction. In vivo studies were carried out by implanting in subcutaneous nude mouse followed by extraction, histological staining. Collectively, superior results were showed by DC/GG sponges than GG sponge in terms of physical property and cell proliferation and thus can be considered as a potential candidate for future tissue engineering applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/42639 |
DOI: | 10.1080/09205063.2016.1213218 |
ISSN: | 0920-5063 |
Versão da editora: | http://www.tandfonline.com/doi/abs/10.1080/09205063.2016.1213218 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18818-JESong-JBiomatSciencePolymEd2016.pdf | 2,11 MB | Adobe PDF | Ver/Abrir |