Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/42496
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Bacelar, Ana Helena Dias | por |
dc.contributor.author | Silva-Correia, Joana | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2016-09-08T09:13:32Z | - |
dc.date.issued | 2016-08 | - |
dc.date.submitted | 2016 | - |
dc.identifier.citation | Bacelar A. H., Silva-Correia J., Oliveira J. M., Reis R. L. Recent progress on gellan gum hydrogels provided by functionalization strategies, Journal of Materials Chemistry B, doi:10.1039/C6TB01488G, 2016 | por |
dc.identifier.issn | 2050-7518 | por |
dc.identifier.uri | https://hdl.handle.net/1822/42496 | - |
dc.description.abstract | Gellan gum, a microbial exopolysaccharide fermentation product of Pseudomonas elodea, is a natural biomaterial that has shown promise for tissue engineering and regenerative medicine applications. Although this exopolysaccharide possesses many advantages, such interesting physicochemical properties and non-cytotoxicity, the mechanical properties and processability of gellan gum are not totally satisfactory in different tissue engineering contexts, i.e. gellan gum hydrogels are mechanically weak and the high gelling temperature is also unfavourable. An additional critical limitation is the lack of specific attachment sites for anchorage-dependent cells. However, the multiple hydroxyl groups and the free carboxyl per repeating unit of gellan gum can be used for chemical modification and functionalization in order to optimize its physicochemical and biological properties. A number of physical modification approaches have also been employed. This review outlines the recent progresses for gellan gum hydrogels and derivatives, and identifies the new challenges in tissue engineering, provided by blending and/or chemical modifications. | por |
dc.description.sponsorship | The authors would like to acknowledge the financial support provided by the Portuguese Foundation for Science and Technology (FCT) through the project EPIDisc (UTAP-EXPL/BBBECT/0050/2014), funded in the Framework of the “International Collaboratory for Emerging Technologies, CoLab”, UT Austin|Portugal Program. The authors also thank FCT for the fellowship grant of J. Silva-Correia (SFRH/BPD/100590/2014) and the distinction attributed to J.M. Oliveira under the Investigator FCT program (IF/00423/2012). | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5665-PICT/UTAP-EXPL%2FBBB-ECT%2F0050%2F2014/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F100590%2F2014/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00423%2F2012%2FCP0177%2FCT0004/PT | - |
dc.rights | openAccess | - |
dc.subject | Blending | por |
dc.subject | Chemical modification | por |
dc.subject | Gellan gum | por |
dc.subject | Hydrogels | por |
dc.subject | Regenerative medicine | por |
dc.subject | Tissue engineering | por |
dc.title | Recent progress on gellan gum hydrogels provided by functionalization strategies | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01488G | por |
dc.comments | http://3bs.uminho.pt/node/18798 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 6164 | por |
oaire.citationEndPage | 6174 | por |
oaire.citationIssue | 37 | por |
oaire.citationTitle | Journal of Materials Chemistry B | por |
oaire.citationVolume | 4 | por |
dc.date.updated | 2016-09-05T15:57:29Z | - |
dc.identifier.doi | 10.1039/C6TB01488G | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Materials Chemistry B | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18798-Bacelar et al 2016_JMaterChemB.pdf | 1,19 MB | Adobe PDF | Ver/Abrir |